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Saturday's clash is the first of five games the British & Irish Lions will play in the run-up to the three-Test series against the Springboks.
The Sigma Lions (formerly known as the Emirates Lions) enjoyed mixed success in Super Rugby this season, but the hosts will be keen to put on a show, particularly with this being the first match the visiting Lions have played on South African soil in 12 years.
Lions head coach Gatland has made 14 changes to the side which beat Japan, with Wales winger Josh Adams the only man to keep his place. Stuart Hogg has been named captain following Alun Wyn Jones's Tour-ending shoulder injury, suffered just seven minutes into the meeting with Japan at Murrayfield last week.