Week 6, Oct. 17, vs. Cincinnati, 1 p.m.
We have two former No. 1 overall picks squaring off in this one in Detroit's Jared Goff and Cincinnati's Joe Burrow. There will also be intrigue surrounding first-round draft picks this year with wide receiver Ja'Marr Chase (Bengals) and offensive lineman Penei Sewell (Detroit). Many reports out of Cincinnati had the Bengals deciding between Chase and Sewell with the No. 5 overall pick. When the Bengals went with Chase, Sewell fell to the Lions at No. 7.
Week 7, Oct. 24, at Los Angeles Rams, 4:05 p.m.
This one will be circled on most Lions fans calendars because it's the first matchup between Goff and former Lions quarterback Matthew Stafford, who were traded (along with two first-round picks and a third-round pick going to Detroit) early this offseason. It will be Goff's first trip back to SoFi Stadium since the trade and Stafford's first contest against the team he spent the last 11 seasons playing for. Goff won his only career meeting against Stafford (Week 13, 2018 in Detroit).