To me. It sounds all really good. Paris Saint Germain can win a record extending 12th French League title this weekend if they beat le havre at home. Its also the first step in a potential treble as theyre still in the Champions League and have a French Cup Final next month. Translation we are coming to the end of the season translation we are coming to the end of the season in translation we are coming to the end of the season in positive end of the season in positive circumstances. I had never thought of a scenario as positive as this because i dont think too much about the future. Whatever comes welcome and i will accept it. I think we are in a splendid moment in every sense of the word. We have almost all the players available. I supporters are very happy and the club has a lot of ambition to achieve something different. This British Sugar season is attractive, it motivates us a lot this end to the season. One of the worlds biggest womens football stars marta says shes retiring from the International Game at the end of the year. The striker is brazils all time record goal scorer and could make her sixth appearance at an Olympic Games if shes selected for her country this summer in paris. Marta will still play Club Football for Orlando Pride where shes also the all time leading goal scorer. Rugby unions womens 6 nations will be decided tomorrow in a winner takes all game between england and france in bordeaux. England havent lost in the tournament for 28 games and that was by france back in 2018. But theyll face a french side unbeaten this year with the ability to stop a sixth successive title for the red roses. We have got to stay on it from the first minute to the 80th minute and if we come off it like we did last time we played them they can turn it on at any time and have that french flair. I think their philosophy is dare to play, but actually we are not going to let them play this week. We starve them of the ball and they cant play. We are ruthless about the way we go about our business and the scoreline will look after itself. The young quarter back Caleb Williams was the first pick at the nfl draft. 250,000 fans packed out detroit for the draft where American Football teams pick the best prospects for the new season. The 22 year old williams is being hailed as the most talented player to come out of college for years and he was the first pick for the Chicago Bears one of a record six quarterbacks chosen in the first 12 with no defensive players in the top 10 for the first time in nfl draft history. The draft continues for another two nights. Nico hulkenberg is the first driver to sign with the new audi formula one team. The german will race for sauber next season before they transform into the factory audi team in 2026. The teams are also targeting ferraris carlos sainz. Hulkenbergs decision leaves a vacancy with his current team haas. Snooker� s World Championship is into the second round and its proving hard going for englands robert milkins. Milkins is a frame away from losing to David Gilbert and his frustration showed earlier as he took it out on his cue. Gilbert leads 12 4 its the best of 25 frames with a place in the quarter finalsd at stake. And thats all the sport for now. Skin Cancer Patients in the uk have begun taking part in a trial aimed at developing the first personalised vaccine for melanoma the deadliest form of the disease. The experimental treatment uses the same technology as some covid i9 jabs. Results from an earlier stage of the trial suggest using it in combination with another drug reduces the risk of recurrence or death by 49 after three years. Heres our health correspondent, jim reed. Could a jab like this change the way cancer is treated . Last month, steve young became the first person in the uk to be given this personalised vaccine, not to prevent the disease, but to try to stop a skin cancer returning. At least by being on a trial, im actively doing something that, you know, im having a fight, basically, im having a fight with whatever it was that gave me a melanoma. Last summer, steve had this tumour removed from his scalp. Those same cancer cells were flown to the United States and used to make the new experimental treatment. By priming, or preparing, his immune system, the hope is that steves own body can better find and attack any cancer cells left over after his surgery. The trials being run at this hospital in london and others are based on the same Technology Used in some covid jab called mrna, combined with a second treatment. Early Research Suggests it significantly reduced the risk of this specific skin cancer called melanoma returning three years after surgery. Researchers hope the same approach could work more widely. The real potential here, of course, is expanding this into other cancers because its not a technology that just works in one cancer. If it works in melanoma, it could work across a number of different cancers, lung cancer, bowel cancer, Kidney Cancer etc. So theres a potential here for a really transformative change in how we treat patients with cancer. For patients like steve, a musician from hertfordshire, the hope is this personalised approach will one day sit alongside proven treatments like radiotherapy and chemotherapy. Weeks on from his treatment, he is thinking about his future. Ifeel like i have this new lease of life and im actually really loving life at the moment, and ijust really hope that whats happening with the trial and the results they get are going to be good news and its going to go on to do amazing things. The uk arm of this global trial is taking place at this hospital and seven other sites across the country. But this is still very early stage research, with full results not expected before the end of the decade. Manchesters new Co Op Live Arena which will be the uks largest music venue has postponed its opening again, this time to may, because it is still not ready. This comes after the boss of the new arena resigned after a series of problems and delays. Gary roden quit his role after comedian peter kays opening shows were cancelled this week because the £365 million venue was not ready to open in time. Our Arts And Entertainment reporter, ian youngs, has the latest. It isa it is a big embarrassment for the venue, which was meant to have opened earlier this week, originally with peter kay playing two nights. Those were then postponed until next week, but now there is a been postponed again until may. So this venue which will hold 23,500 people still hasnt opened adders after a rocky start. As for what has gone wrong, the venue said they have, they need more time to test the emergency Communication Systems to ensure the venue is safe and all the areas can be open to fans. But yes, it is definitely having some troubles getting fully open. The boss has Quit Troubles getting fully open. The boss has quit his role, what has he said . , ,. Said . Yes, he resigned yesterday. He hasnt spoken said . Yes, he resigned yesterday. He hasnt spoken publicly said . Yes, he resigned yesterday. He hasnt spoken publicly yet, said . Yes, he resigned yesterday. He hasnt spoken publicly yet, but said . Yes, he resigned yesterday. He hasnt spoken publicly yet, but his hasnt spoken publicly yet, but his decision came in light of the initial delay and presumably in advance of todays developments. He had been criticised also for a row with Grassroots Music venues in the uk who had called for a subsidy from big arenas, but he dismissed that, saying some Grassroots Music venues were poorly run and their campaign was quite aggressive, and so that added to the negative publicity. Finally this hour, i want to show you some stunning pictures from florida. This is aprils full moon or the pink moon in all its glory over navarre beach. Maybe surprisingly it doesnt take its name from its appearance but is based on what Native Americans used to call it naming it after the herb moss pink. Just before we go, reminder donald trump is back in court over his Hush Money Trial. Trump is back in court over his Hush Money Trial money trial. This is the scene outside the money trial. This is the scene outside the courthouse money trial. This is the scene outside the courthouse now, | money trial. This is the scene outside the courthouse now, where donald trump arrived a short time ago. He gave a statement to the press, thanking everyone for being there, wishing his wife a happy birthday. Was also critical of the court and the judge involved birthday. Was also critical of the court and thejudge involved in birthday. Was also critical of the court and the judge involved in this case, as he has been all along. We know the trial is now back under way, and im just having a look for the latest from there. David packer is back on the stand for cross examination. He gave evidence yesterday. This is the former National Enquirer publisher, you will answer more questions about his efforts to suppress damaging information about donald trump during the 2016 election, as the trial continues. He is facing questions from Donald Trumps lawyers, who want to show the tabloids practice unflattering stories about him and it was established before he ran for president. Donald trump denies all the charges and has pleaded not guilty. Plenty more on that story and all the rest of the days story on our website. To stay here on bbc news. Thank you for watching. Hello. It was a really cold start to the day. A widespread frost. Lowest temperatures down to 6 in the coldest spots in both Northern England and scotland. But many of us have seen sunny skies like these already. It is a day, though, where clouds will bubble up to bring showers. And weve seen lots of showers in northern ireland. There have been quite a few for the north and east of scotland, and down the eastern side of england. Meanwhile, this thicker Cloud Affecting Southern Wales and southern most areas of england. Well, thats a Weather Front bringing more general outbreaks of rain. Now, the rain from thats going to be light and patchy into southern wales. Just a few spots really. Some heavier rain getting into south west england. Those showers become a bit more widespread across Northern England, probably popping across the pennines into the north west of england. Well continue to see quite widespread showers for northern ireland, northern and Eastern Scotland down the eastern side of england. But it will be northern and central wales, the midlands, east anglia that stay largely dry today. Overnight, a band of rain moves up from the south, that will keep temperatures up around six or seven degrees. But away from that, with the clear skies, again, were looking at a cold night with a widespread and sharp frost. The weekend will be dominated by this area of low pressure moving up from the south. Now, we are looking at some rain developing on saturday across southern counties of england, wales, midlands and east anglia. And as well as the rain, there will be a Chilly Northeasterly wind developing through the day. Maybe as the rain clears, we could see some heavy showers following to southern areas of england. Elsewhere for scotland, northern ireland, the far north of england, its another day of sunny spells and passing showers. After that cold start, wherever you are, temperatures not doing great for the time of year. For sunday, low pressure still with us. Outbreaks of Rain Extensively across england, reaching Eastern Scotland through the day. Its Western Areas that will have the best of the days weather. Sunshine, and again, a few sharp showers. It is another cold day, but the last of the cold days well see for a while because the weather is set to turn a bit milder. Well start to see that change on monday as the winds come up from more of a southerly direction. There will be some rain across Western Areas. The driest, brightest weather will be across eastern areas of the uk. But those temperatures will be climbing much closer to average for this time of the year. And that Warming Trend is set to continue deeper into next week. Could see temperatures reach the high teens, the low 20s in the warmest spots. However, there will be some rain to come as well. Live from london. This is bbc news. Americas top diplomat tells the bbc hes prepared to take steps against china if it continues to support russias war effort. If you want have better relations with us in countries in europe, it cant do that at the same time. As the worlds first personalised vaccine for melanoma skin cancer is being tested, well speak to a melanoma survivor about why this is a potential gamechanger for treatment. Donald trumps criminal trial on charges of falsifying Business Records to conceal a Hush Money Payment to a porn star continues. Im outside the court room where the defence has just started cross examining a Tabloid Executive who said he