Finally, vaccines are being produced that might help us return to Something Like the lives we had before covid. Here in the uk, over 10 million doses have already been given out, but at the same time, the virus is Mutating First here in the uk, then in brazil and south africa. So, scientists are turning their attention to how to adapt vaccines to make sure they work against all new variants. Astrazeneca and Oxford University say they plan to have a Next GenerationCovid Vaccine ready for the autumn. Our medical editor fergus walsh reports. The scientists at oxford who created the astrazeneca vaccine are continually monitoring how coronavirus is evolving. The current vaccine is thought to give good protection against new variants, but theyre working on tweaking the jab to make it future proof. The scientist whos leading the Research Says its relatively simple to redesign the vaccine. Its not difficult to put a different Antigenic Insert into the vaccine, so we dont want to panic and say that we must have a new version of the vaccine now but on the other hand we are getting prepared, so that if it turns out we do need a new version, it will be ready to start using it. Itsjust going to be a sharp scratch, ok . Those on the oxford vaccine trials were shown to have 76 protection from a single dose, which lasted three months, rising to 82 protection, with the second shot. Well be doing swabs every week at home. It is also the first time a Covid Vaccine has been shown to reduce transmission of coronavirus. Those immunised were much less likely to test positive for infection, cutting the risk of them passing the virus on to others. Thats the vaccine, but what about those who have actually had covid . They want to know how long they may be protected against subsequent infection. A study involving nearly 20,000 volunteers may provide at least part of the answer. Like the other participants, i was asked to send off a few drops of my blood every month to a lab. Scientists at uk biobank found that 88 of us, nearly nine in ten, who started off with antibodies, still had them six months later. These findings are really good news, because it does suggest that people who have been infected with the virus may have some degree of protection against another infection for some considerable time. What we would really like to know next is, how long does this Natural Immunity last for beyond six months . Scientists think vaccines are likely to offer much stronger protection than natural infection, so a key message is to get immunised, even if you have already had covid, to boost your immunity and maybe protect others. Fergus walsh, bbc news. In portugal, hospitals are struggling to cope with a sharp rise in coronavirus cases. In fact, the nation has seen some of the worlds highest rates of new infections in recent days, and nearly half of portugals 13,000 Covid Fatalities occurred just last month. Its a worrying turn for a country that had been doing better than its european neighbours in battling the outbreak. Mark lowen reports. Shes weak, exhausted by just a few steps. But, overwhelmed by the third wave, portugal had no ambulances to bring her in. So her husband, mario, had to take her to the countrys largest hospital close to collapse. Portugal currently with the worlds highest rate of infections and deaths. The main problem is the fact that i can, here, put another person, a lot of persons, in danger because there is always the situation that i can pass my sickness or my wifes sickness to the other people. The bbc was taken inside Santa Maria Hospital and to the frontier of portugals battle. Beyond these doors, an Intensive Care Unit with just seven of its 70 beds still free. One medic filmed for us in the hell of the storm, some working 18 hour shifts. The british variant is spreading like wildfire, behind half of portugals cases. One of the eus most Fragile Health Systems is now critically short of resources. Nurse Patricia Fonseca nunes says only Covid Patients are coming all other surgery has stopped. The emotional burden is immense. Well, i can tell you i remember all of my patients who died. I remember theirfaces, i remember their names, i remember their families. I remember the 22 year old who woke up to me and asked me, what happened to my legs, am i going to be able to play my soccer again . I get so frustrated and so sad when people tell me this is not happening. Sometimes i just want to take them by the hand and say, come along, come with me, come and see how it feels like to be losing people. Today, germany flew in doctors, ventilators and dozens of beds to help. European partners keen to show theyre pulling together after being criticised for throwing up walls in the first wave. Portugal has now tightened a lockdown that it briefly lifted over christmas, a move partly blamed for the new search. I think the responsibility is more people on ourselves and less on the government. They are trying their best. On the new surge. There are many people dying for days. It is something not normal. Honestly, very scary, yeah. Portugal has gone from weathering the early pandemic to an unlikely global epicentre, as the virus rages through europes westernmost shores. Mark lowen, bbc news. In myanmar, police have filed criminal charges against the civilian leaders who were deposed in a military this week. Theres been no word on the whereabouts of either Aung San Suu Kyi or president win myint since monday. In a Military Coup. The United Nations said the charges just � compounded the undermining of the rule of law in myanmar and the democratic process, and they called for the Immediate Release of the leaders. For a second day, protesters banged pots and sounded car horns in the countrys largest city. Our reporter Nyein Chan Aye has filed this report from yangon. People are showing their frustration and anger against the Military Coup. It has taken place on monday. People in general have been banging pots and pans in protest against the Military Coup that took place on monday. Essentially, what people here are saying is they dont want to live or work under the military any more. Singing. Translation we only respect our elected president , and no one else. If the president wanted the military to take over, we would have accepted that, but this coup is not fair so were expressing our feelings in a peaceful way. Were the voice of the little people. Translation | witnessedl the coups in 1962 and 1988. We know about what happens under military takeovers, so we have to do this. If we take to the streets, they will shoot us instead. Under these circumstances, i support this kind of protest. We want the elected leaders back. Translation people dont accept the coup. J thats why we want to drive them out by doing this. On the other hand, the military is taking total control of the country. The military has installed 11 members who will rule under state of emergency. The people have come out here again in less numbers than yesterday to say they want their vote and voice to be heard. Nyein chan aye, bbc news. Lets get some of the days other news. Nancy pelosi, the democrat speaker of the us house of representatives, has confirmed therell be a full vote on thursday about whether to strip a republican representative of her role on two key congressional committees. Marjorie Taylor Greene from georgia is said to have encouraged bogus Conspiracy Theories and made anti semitic comments online. The us treasury secretary, janet yellen, has called a meeting of top officials that could result in tougher Financial Market regulation. Mass buying by Amateur Traders many of them active on reddit forums has led to volatility in some Company Share prices, including gamestop and amc entertainment. The issue of the farmers protests has attracted the attention of International Stars and activists, who have criticised the response of the indian government. Rihanna, greta thunberg, and meena harris, the niece of kamla harris, have all voiced their solidarity with the protestors who are demonstrating against agricultural reforms. Indias Foreign Ministry labelled the comments neither accurate nor responsible. Canada has designated the proud boys as a terrorist entity, joining a list that includes al qaeda and the Islamic State group. The all male, anti immigrant group, which describes itself as western chauvinist, was founded by a canadian. Some members were among the supporters of donald trump who stormed the Us Capitol Last month. Jess davis is an Intelligence Analyst and president at insight threat intelligence, based in ottawa. Shejoins me now. First of all, the common perception that proud boys are an American Organisation only, but you said there are plenty of canadian members in that group two. How popular are the proud boys and canada . Its proud boys and canada . Its hard to put proud boys and canada . Its hard to put a proud boys and canada . It� s hard to put a number on how popular they are but we know that there are chapters of the proud boys across canada, and there are different points, there are different points, there have been tens, 20s, they be in the hundreds. People who are affiliated with the proud boys and canada. They also have something of a Different National presents. Something of a Different National presents. Something of a Different National resents. ~. ,. , national presents. What are the Implications National presents. What are the implications of national presents. What are the implications of this national presents. What are the implications of this ruling national presents. What are the implications of this ruling in implications of this ruling in canada . ,. , implications of this ruling in canada . ,. , , canada . Generally speaking, the Terrorist Listing canada . Generally speaking, the Terrorist Listing process Terrorist Listing process doesnt tend to have a lot of implications. Our Law EnforcementSecurity Services can conduct investigations regardless of whether a group is designated or not, but in the case of the proud boys, the implications are much more significant because there are so many more members in canada and pretty much any other Terrorist Group on that list. And the other thing about that is a lot of have been publicly identified through protest. Theyve been identified docs if you will, so theres a lot of people in canada who have been publicly identified as members of this now terrorist organisation. It of this now terrorist organisation. Of this now terrorist or anisation. ,. , of this now terrorist oruanisation. ,. , organisation. It was founded by canadian. Organisation. It was founded by canadian, wasnt organisation. It was founded by canadian, wasnt it . Organisation. It was founded by canadian, wasnt it . Thats canadian, wasnt it . Thats correct canadian, wasnt it . Thats correct it canadian, wasnt it . Thats correct. It was canadian, wasnt it . Thats correct. It was founded canadian, wasnt it . Thats correct. It was founded in i canadian, wasnt it . Thats i correct. It was founded in the united states, though, so i had that transnational quality. Would you expect a similar kind of ruling in the us . Obviously the constitution is different there. I the constitution is different there. ,. , there. I would expect it to be uuite a there. I would expect it to be quite a bit there. I would expect it to be quite a bit of there. I would expect it to be quite a bit of a there. I would expect it to be quite a bit of a different quite a bit of a different process in the us. There deck and the nations their designations are different processes. In canada, the majority of implications are financial, whereas in the united state, it would be a different way of going about doing that. Different way of going about doing that doing that. How does this rulin doing that. How does this ruling doing that. How does this ruling what doing that. How does this ruling what does doing that. How does this ruling what does this l doing that. How does this i ruling what does this tell ruling what does this tell us about the threat posed by proud boys . Us about the threat posed by proud boys . Us about the threat posed by proud bo s . ,. , proud boys . Not much about the threat because proud boys . Not much about the threat because the proud boys . Not much about the threat because the designation. Threat because the designation comes after many years of proud boy activity and canada and it doesnt accompany any other information about the activity. Primarily referencing some vague counter protest activities and more specifically, about the advance on capitol hill. It is and give us more information about how active they are in canada or what they might be intending to do. , , what they might be intending to do. � , , what they might be intending to do. , � , what they might be intending to do. , do. Jess davis, its been really and do. Jess davis, its been really and still do. Jess davis, its been i really and still interesting do. Jess davis, its been really and still interesting to talk to you. Stay with us on bbc news. Still to come hollywood pushes ahead through the pandmic with the start of its awards season. Well tell you why this years Golden Globe Nominations are making history. This is the moment that millions in iran have been waiting for. After his long years in exile, the first hesitant steps of Ayatollah Khomeini on iranian soil. South africas white government has offered its black opponents concessions unparalleled in the history of apartheid. And the anc leader, nelson mandela, is to be set free unconditionally. Three, two, one. A countdown to a critical moment. The worlds most powerful rocket ignited all 27 of its engines at once. And, apart from its power, its the recycling of the rocket, slashing the cost of a launch, that makes this a breakthrough in the. Business of space travel. Two americans have become the first humans to walk in space without any lifeline to their spaceship. One of them called it a piece of cake. Thousands of people have given the yachtswoman Ellen Macarthur a spectacular homecoming in the cornish port of falmouth, after she smashed the world record for sailing solo Around The World nonstop. This is bbc news, the latest headlines. Scientists at Oxford Univerity and astrazeneca say theyre working on the Next Generation of Covid Vaccines so that the jab can be adapted to to deal with any new variant. Protests continue in myanmar as the un urges the world to make sure mondays Military Coup, which removed leader Aung San Suu Kyi, fails. The uk and the eu have said that they will Work Together to find solutions to the problems around checks for some goods being transported between Great Britain and Northern Ireland. There were talks today between the Cabinet Office minister, michael gove, the European Commission and the stormont executive. The talks have been taking place amid growing tensions, after the Commission Proposed controlling the flow of vaccines across the irish border last week. Our ireland correspondent emma vardy has the latest. Getting a lorry load of food over the irish sea is all in a days work, here. But, since our separation from the eu, it has become more complicated. We never knew what brexit was going to look like until the final deal happened, and the systems were not rolled out until the end of december. What have things been like since january 1st . It was mayhem in the first 21 days. People were not sure of the paperwork. Border checks were not put into place, we took seven days to understand the process. It has improved greatly, but it is not there yet. Whats really worrying businesses here is that from april, there will be even more red tape, when an initial grace period expires. Now the government is asking the eu to push that back by nearly two years. Why is this needed . We need this grace period extended to give companies more time to prepare for these changes. They simply didnt have the time to make the changes necessary, so it will give us time to come up with more long term solutions. What happens if the eu stand really firm on this . The eu has to acknowledge that Northern Ireland just didnt have the time to prepare for this and they have to realise that this is impacting our supply chains, especially around food. The difficulties over goods coming from britain into Northern Ireland have led to unease between communities here. Unionists see a new border in the irish sea as undermining Northern Irelands place in the uk. Yesterday, eu staff and officials that carry out checks on food at the ports of belfast and larne were stood down after concerns over threats to their safety. I think both the European Union and westminster government the physical Border Checks here are on hold for a second day. The uk government is hoping that getting more flexibility from the eu around the rules will help de escalate tensions here, but Northern Irelands democratic unionists want them to go much further. The protocol has betrayed us, and has made us feel like foreigners in our own country. Tea and sympathy will not cut the mustard. We will do everything we need to do, mr speaker, whether through legislation or by invoking article 16 of the protocol, to ensure that there is no barrier down the irish sea. The way ahead may depend on how much the eu is willing to bend. There were no immediate concessions. There were no immediate concessions. ~ , concessions. The Prime Minister needs to follow concessions. The Prime Minister needs to follow that concessions. The Prime Minister needs to follow that through needs to follow that through the actions. Well be pushing him to do that. The actions. Well be pushing him to do that. Their solutions and the way him to do that. Their solutions and the way in him to do that. Their solutions and the way in which him to do that. Their solutions and the way in which we him to do that. Their solutions and the way in which we will. Him to do that. Their solutions| and the way in which we will do that is and the way in which we will do that is work with the agreement, and make provision for committees to come together. For committees to come together for committees to come together. For committees to come touether. ,. , together. The way ahead may deend together. The way ahead may depend on together. The way ahead may depend on how together. The way ahead may depend on how much together. The way ahead may depend on how much the together. The way ahead may depend on how much the eu | together. The way ahead may l depend on how much the eu is willing to change course. Emma vardy, bbc news. Hundreds of players, officials and support staff at the Australian OpenTennis Championship will go into isolation, after a worker at one of the events hotels tested positive for coronavirus. Tomorrows play at the warm up events at Melbourne Park has been cancelled as a result. Players will be free to return to the competition after a negative test, and the organisers expect 2021s first Tennis Grand Slam to go ahead as planned on monday. The premier of the state of victoria, daniel andrews, has been speaking in the last few moments. Theres been a very big team of people working throughout the night and will continue working until we have absolute control of this. There are many, many hundreds of people whove been contacted. The number of exposure sites, as we predicted last night, has grown. Its very important that people get the best information, and then make the decision to go get tested. Our correspondent phil mercer is in sydney. He says the run up to this years open seems destined to be remembered for covid i9 rather than tennis. Australias response to the pandemic has always been to go hard and to go early. And thats certainly what the victorian State Government is doing. There are fears that this 26 year old support worker who was stationed at one of the hotels for the Australian Open in melbourne has been in contact with hundreds of people. Now australias response to the pandemic it closed its borders to foreign travellers back in march, mass testing, about 13 million tests have been carried out since the pandemic began. And also, very sophisticated Contact Tracing too. So the premiere of victoria state, danielandrews, is urging people not to panic, and he says the authorities know how to get on top of these outbreaks. And phil, very briefly, it will go ahead, wont it, despite all thats happened . Yes, you would imagine it would. There might be a few bumps along the way, and certainly thats been the case since hundreds of players and support staff were flown into australia. And the Australian Authorities are extremely determined to make this event happened, but also to happen, but also to make it safe as well. So the authorities, iwould imagine, would be crossing their fingers that they can get on top of this particular outbreak, so that play in the Australian Open can begin as scheduled on monday of next week. Movie theatres are closed in many parts of the world due to the pandemic, but the hollywood awards season began in earnest today, with the announcement of the golden globe nominees. And history was made, with three women nominated in the best director category. Among them chloe zhao, who directed the movie nomadland. Shes the First Chinese film maker to to be nominated for the category. Our entertainment correspondent tom brook spoke to her in los angeles. Im not homeless, imjust. Chloe zhaos picture nomadland, starring frances mcdormand, is a contemporary western, the story of a woman who leads a nomadic life in americas heartland. Its been playing at festivals and at their drive in venues, and its generated a lot of awards buzz. For 38 year old zhao, this, her third film, is a major achievement. Shes made history by becoming the first woman of asian descent to land a golden globe best director nomination. Obviously, shes pleased by the recognition. I think its great, i think its very happy. I love what i do, and anything that can help me keep doing what i love to do, ill take it. Last year, the south korean movie parasite won the top Best Picture Trophy at the oscars. Now, with chloe zhao earning a golden globe nomination, it suggests that hollywood is becoming more open to embracing asian storytellers long marginalised by the industry, especially women. These things do inform, i think, investors and gatekeepers to look at what kind of stories and what kind of talent they invest in. This means that more people that look like me get to do it, and i think thats great. Zhao could also make history by becoming the first asian woman to be nominated for an oscar for directing. Film critics see the recognition shes being given as very significant. Its a huge breakthrough. Asian americans and asian people specifically have been really marginalised in hollywood, and its proven that they no longer have to adhere to certain rules and regulations to have their stories made. But they can do what they want and show all that they are and all their texture and colour and bring that to therefore making history. The awards recognition is going to help boost the profile of zhaos film nomadland. With its emphasis on american lives being dislocated, it has topical currency. I think its speaking to anyone who feels like theyre weighted down. This pandemic sort of showed us things cant go away overnight, and how do you keep going. Hello, coffee . Zhao has developed her career by independent films shaped by her strong personal artistic choices. Her next movie is the internals, a big budget marvel superhero extravaganza. Itll be interesting to see if her singular vision, as witnessed in nomadland, prevails in the film which is much more commercial. Tom brook, bbc news, new york. You can reach me on twitter im bbcmaryam. This years Super Bowl Stadium will be rather empty do to health and safety profiles. The nfl invited 7000 care workers to be at the game safety protocols. To fill the rest of the seats, the legal match the fanned in the Stand Cut Out Programme that lets people upload a photo. Cut out cost 100 with a portion of the proceeds being to local charities picked up by the fans home team. Unfortunately, the programme is already sold out. Thats it from me. And you so much for watching. Youre watching bbc news. Bye bye. Hello there. Winter is about to ramp up to another gear by the end of this week, certainly into the weekend. Itll be turning much colder with the risk of some disruptive snow in places. So for the next few days, itll gradually be turning colder for all, and well see increasing snow particularly over the hills in the north. Now for thursday, weve still got low pressure close by to the uk, its the Weather Front across the north bringing further cloud, outbreaks of rain to Northern Ireland, much of scotland, Northern England too, and here well see further snow over the scottish hills accumulating and drifting in that strong east southeast wind. Further south, after a bright start to the day, well start to see showery bursts of rain moving up from the south. Here, itll tend to be fairly mild, 8 10 celsius, but very cold across the north where we have that snow. Through thursday night, it continues with rain and the snow across scotland significant accumulations over the grampians and the highlands, very wet weather with a risk of flooding. Further south, a drier night to come and clear skies, could see some mist and fog across southern england, and again, a big temperature contrast from north to south. Now the snow continues as we head on into friday and saturday significant accumulations have prompted the met office to issue an Amber Warning for this heavy, incessant snow. And also, some very heavy rain for lower levels could cause some localised flooding so a whole host of issues there. Further west, well have sunny spells, a few showers, tends to stay dry across the far southeast again, 9 10 celsius, much Colderfurther North where it will also be windy with that drifting snow in the hills. Moving on into the weekend, our area of low pressure sinks a bit further southwards, so it means the rain and the hill snow across Scotland Will Drift into parts of Northern England at times too, so a whole wintry mix here could be disruptive. Further south, quite a bit of cloud around with outbreaks of rain, and temperatures dropping generally across the board. Still cold in the north and a little bit colder for much of england and wales, too. As we head on into sunday, the very cold air across the east pushes southwards right across the uk, and itll be very windy, so the wind making it feel even colder 2 3 celsius, some snow pushing into northern and eastern areas which could be disruptive. So turning very cold through this weekend for all areas, with the risk of some disruptive snow for some of us. This is bbc news, the headlines. Scientists at Oxford Univerity and astrazeneca say theyre working on the Next Generation of Covid Vaccines so that the jab can be adapted to work against different strains of the virus. The virus is already Mutating First here in the uk, then in brazil and south africa. Protests are continuing in myanmar as the un urges the world to make sure mondays Military Coup fails. Deposed de facto leader, Aung San Suu Kyi, has been accused of breaching the countrys strict import and export laws and illegally possessing two way radios. Canada has become the first country in the world to designate the far right anti immigrant Proud Boys Group as a terrorist organisation. Some members were among the supporters of donald trump who stormed the Us Capitol Last month. They nowjoin a list that includes alqaeda and the Islamic State group. Now on bbc news, its hardtalk with stephen sackur