Stronger. Scientists develop a gene test informing women how likely they are to develop Breast Cancer. It could soon be used on high risk groups. Also this hour the race across australia, fuelled by sun. Teams from around the world compete in ani,800 mile solar powered chase. It aims to Show Technology which could one day be used on our roads. In sport, Northern Ireland seals a place in the world cup play offs but theres disappointment for scotland. Good evening and welcome to bbc news. Hundreds of thousands of people were on the streets of barcelona in a huge show of support for the unity of spain and against plans for the independence of catalonia. Spains worst political crisis for decades was sparked a week ago by a referendum on independence for the wealthy North Eastern region. Its home to around seven million people. Its government had said it planned to go ahead with a declaration of independence in the wake of the vote. But spains Prime Minister has warned of drastic action if that happens. From barcelona, our europe editor katya adler reports. Catalans who oppose independence from spain call themselves the silent majority. Today they made a lot of noise. We want to stay together. We dont want to break this country. I am catalan. I am spanish. And today im here because im very proud. And i dont want that catalonia go out of spain. Everyone we spoke to here was catalan but people came from all over spain in the name of spanish unity. This crowd is emotional, excitable and passionate because this is all about identity. Their identity. Whether catalonia remains in or outside spain but the power of emotions aside, today is also all about politics. The question here for the spanish Prime Minister, will he wait for the Catalan Government to declare independence or act first . His answer in a rare televised interview today. Translation be absolutely reassured, the government will prevent any declaration of Catalan Independence from turning into something real. Spain will continue to be spain. It is what the majority of spaniards want. Maybe but catalans remain split fween familiar lanes friends where tensions remain this week. Im worried independence will happen in 48 or 72 hours and i havent heard have a clear expansion of how things are going to woncht i dont know if im going to be in europe, if i will be using the euro. We have two countries, spain and catalonia. My heart is divided. Im excited with the idea of creating a new country but im worried too. My friends are very, very worried. But ardent Pro Independence catalans arent concerned. Theyre elated. They view the Spanish Government as oppressive and identify with the catalan language and culture, not spanish. The number of pro catalan voices have been growing in the last few yea rs. We are waiting for a long time. Im excited. Last week catalans held an independence referendum not recognised under spanish law. So now will the Catalan Government fulfil their promise, declare independence and risk a strong response from madrid . Talking to an mp from the governing party that seems increasingly unlikely. A kind of yes, but. We are sure and we have understood that the majority of catalans want this country to be an independent style. We are ready to talk, negotiate with the catalan, with the Spanish Government, in order to make this effective. That does not sound like a unilateral declaration of independence. This is the point. But by now the point from many catala ns, whatever their political persuasion, is to avoid deepening divisions, between fathers and sons, colleagues and cousins. After days of colourful flag waving, a heartfelt plea for dialogue. Katya adler, bbc news, barcelona. Theresa may says she is not someone who gives up, despite moves against her by some of her mps in the wake of her faltering Party Conference speech. The former Prime Minister sirjohn major today accused those conservatives who are seeking to undermine her of being self absorbed and disloyal. Heres our Political Correspondent chris mason. After a turbulent week, a chance for quiet contemplation. The Prime Minister and her husband arrive at church this morning. Theresa may wants to be seen to be getting on with it. By this afternoon, shed swapped a pew, for the streets of her berkshire constituency. She told a sunday newspaper her calamitous Conference Speech was uncomfortable but should be kept in proportion. Enter next, offering support, this man, sirjohn major, who knows what it is like to be a Prime Minister under pressure. It is time to put up or shut up. He saw off his internal critics two decades ago. Now he wants to help theresa may do the same. Those undermining her, he said, were undermining not just their party but the government too. And from a former Prime Minister, to a future one, at least in the dreams of some tory activists. Both with the same message. Weve seen some quite unfortune tune ate shenanigans of people trying to push, but the pushback is strong, we are behind the Prime Minister, she is the best person to lead us forward. Reporter are you fully behind the Prime Minister . The foreign secretary, seen by some to be perpetually in the running for the top job and mrs mays chief irritant, said today those trying to topple here were nutters but could, should the Prime Minister sack or move him . If you put back boris on the backbenches he will take to the hustings, all over the country and all over the media. The only way you can avoid leaving him as foreign secretary, with all the difficulties thats created, is to give him a job which is essentially domestic, but you give anyjob to boris and he will still be boris. Downing street sources say talk of a ministerial reshuffle is speculation but some say it is time for theresa may to freshen up her team in terms of a reshuffle. In terms of a reshuffle, because shes staying and because shes going to remain in thatjob and we want her to remain, she has to come out fighting next week. One of the things she will have to do is assert her authority. I think one of the ways to do that is to have a reshuffle and bring in some of the brilliant talent. Tomorrow, mps return here to parliament. The Prime Minister will be reassured that a series of tory heavy hitters and others have rallied behind her. But, it is an indication too of how precarious her position is perceived to be. Chris mason, bbc news, at westminster. The snp leader Nicola Sturgeon says she wont think about the timescale for another Scottish Independence referendum until the brexit deal becomes clear. She had previously talked about holding a second vote as early as next autumn. And, as the Party Gathers in glasgow for its annual conference, some believe its focus should shift to a second referendum on brexit. Our Political Correspondent iain watson reports. The political weather has been changing in scotlands largest city in recent years. Once a labour stronghold, the council is now run by the snp. And the majority of voters in glasgow backed independence in 2014. Earlier this year, Nicola Sturgeon suggested there could be another independence vote as early as next autumn, but in this city this morning, her timescale sounded far more flexible. There are many people i think in scotland who desperately want to see scotland become independent. There are others who are not convinced and wholl never be convinced and there are others who perhapsjust think we need a bit of dust to settle on brexit. Whats changed . Well, theres the small matter of a general election where the snp lost one third of the seats at westminster and now this conference, an snp conference remember, independence isnt even formally on the agenda and privately, some of the most senior figures in the party are saying, dont expect to see a second independence referendum before the next Scottish Parliament elections in 2021. And heres perhaps the reason why the snp leadership are reflecting on the timescale for independence. Is it odd that independence doesnt feature as a formal item on the agenda . Well, you know, we are damned if we do and damned if we dont. This is the party of independence. Of course we have the brexit bill coming back to parliament. We need to make sure we are arguing for our National Interest in that which is about staying in the single market. So the snp say their immediate priority at westminster will be to work with others to oppose conservative legislation on leaving the eu, but some semoir Party Figures are saying privately that they should go further, that the referendum they should be arguing for isnt won on independence but on brexit. And that seems to reflect the view of Pro Independence voters here in glasgow. No, i think she should just hold her horses and kind of wait. I wanted independence. I wanted to stay in the eu. However, i think the people of scotland have kind of spoken. This autumn, expect the snp to continue to put clear blue water between them and the government on brexit. But also expect to see far less focus on a second Scottish Independence referendum. Iain watson, bbc news, glasgow. The row between the white house and american Football Players whove been kneeling during the National Anthem in protest at Racial Injustice has resurfaced. The us Vice President mike pence has walked out of a game in indiana because some of the players knelt. President trump tweeted tonight to say hes proud of him. Lets get the latest from our washington correspondent, laura bicker. Well, this looks like a very much planned walkout by the Vice President. It should have come to. No surprise to mike pence that the players on the field, the San Francisco 49ers, knelt during the National Anthem. They have done so for the last three weeks. In fact it was one of those players who started the debate in the first place. So as the debate in the first place. So as the players kneeled during the National Anthem, mike pence stood next to his wife and on heart, waited for the anthem to finish and then he walked out. And with that swept walkout he has reignited the debate between the nfl and the administration. President trump took credit, said it was his idea, and that he was proud of his Vice President. He relishes this row because it plays to his blue collar rustbelt based to take pride in the flag, take pride in the National Anthem. For them it comes first. But if it was a stunt it was a risky one. Not only could it stop further division in this country, it could have been quite costly. The Vice President of the air force two, which would have cost hundreds of thousands of dollars, and of expensive stunt to basically score points for team trump. President trump has promised to, in his words, take care of iran. In a television interview, mr trump again criticised the agreement, negotiated by his predecessor, president obama, which lifted sanctions on the iran in return for restrictions on its nuclear activities. I believe theyre funding north korea. I believe theyre trading with north korea. I believe theyre doing things with north korea that is totally inappropriate that doesnt pertain to the deal. But in my opinion it does because its called the spirit of the deal. And you will see what i will be doing in the not too distant future. But iran is a bad player, and they will be taken care of as a bad player. The man arrested after a car crash outside Londons Natural History Museum yesterday has been released by police, but remains under investigation. The 47 year old was one of 11 people hurt when his toyota prius mounted the pavement and hit pedestrians. Police said the incident was a Traffic Accident and not terrorism related. The headlines bbc news in barcelona hundreds of thousands demonstrate for unity in hundreds of thousands demonstrate forunity in spain hundreds of thousands demonstrate for unity in spain following catalonias band independence referendum. Theresa may says she is determined to carry on as Prime Minister as former leader sirjohn major calls for an end to tory infighting. As the snp conference gets under way, Nicola Sturgeon says she wont think about a timescale on a second independence referendum until the brexit deal becomes clearer. Sport now, and for a full round up, from the bbc sport centre, heresjohn watson. A disappointing and frustrating night for scotland. They needed to wina night for scotland. They needed to win a guaranteed place but they could only manage a draw. Leigh griffiths opening the scoring but then their opponents scoring twice. Scotla nd then their opponents scoring twice. Scotland then drew but could not force a winner as they again failed to qualify for the world cup. Obvious disappointment but nothing is the disappointment of the players felt. You could see them at the end of the game. As i said to them, you could go away proud. You push yourself to places some people thought you could not go. The english manager calling for his team to play with more freedom. They secured a narrow victory. The goal coming from the penalty scott. Hurricane with his second goal in four days. The performance did not dazzled their manager. We came away looking a little bit flat. Today, on the act of the other night, we wa nted the act of the other night, we wanted to score a load of goals and when you do not score a load of goals, you understand the reaction. Confirmation that england topped the group. Scotland secure second spot and a possible play off place. Northern ireland made the play off shortly before being beaten i o Northern Ireland made the play off shortly before being beaten 1 0 by norway. And on goal consigning michael oneals side to defeat in their match in oslo. Lewis hamilton says his is taking nothing for granted in the world title race despite opening a huge lead in the japanese grand prix. He started from pole and went on to win for the eighth time this year. He leaves by 59 points with four races in the season 59 points with four races in the season remaining. He is confident of winning his fourth world title with Sebastian Vettels ferrari breaking down having to retire afterjust four laps. Tyrrell hutton has defended his title. He secured a two shot victory with a final round 66. Holding off a late challenge from ross fisher who is 61. It sets a new course record. He went a £600,000 wins. Great britains Claudia Fragapane has won a world bronze medal in the floor at the world gymnastics championships in montreal. The 19 year old finished behind japans winner, mai murakami and jade carey of the usa the result means gbs gymnasts leave canada with two medals, after max whitlock took pommel gold yesterday. I was so disappointed not to get in the final in rio and to be able to come out at worlds and get runs. All that had has gone away and i am so all that had has gone away and i am so happy and grateful. Great to see her getting a medal this time round. Thats all the sport for now. Ill have more for you in the next hour. But first lets have a quick look at some of the front pages. The ft highlights comments from the outgoing german finance minister and his warning that spiralling levels of global debt and liquidity present a major risk to the world economy. The metro chooses to focus on an investigation that shows sexual abuse of children by other children has soared by nearly three quarters over the last four years the daily express concentrates on brexit, claiming theresa may will warn eu chiefs that not enough progress is being made, and brussels must stop stonewalling. The times also says the Prime Minister will warn eu leaders that britain wont make more concessions on brexit until they compromise on opening trade and transition talks. While the guardian reports that Philip Hammonds treasury is being accused of anti brexit gloom. The i says the Prime Minister is getting a grip on her position as leader, and may sack borisjohnson. The Daily Telegraph is predicting thousands of shops and businesses will ignore the deadline to stop accepting old one pound coins, despite warnings that it could create chaos. And the daily mirror report that many of us are now paying for private waste collections with most households having to wait a fortnight for their rubbish to be cleared. Scientists whove developed a new gene test for Breast Cancer say that it could cut the number of women having surgery in case they develop the disease by a third. The tests been developed in manchester, if proved successful, it could be rolled out across the nhs. Our health correspondentjenny walronds report contains flash photography. They have a friendship forged through a fight against cancer. They we re through a fight against cancer. They were tasted for a mutation after losing family members to breast and ovarian cancer. Charlie was a carrier and was given an 80 chance of getting dressed counts. Any 50 . Asa of getting dressed counts. Any 50 . As a result, both had mastectomies. 87 is pretty high so ijust wanted to get rid of them as soon as i could. Had the risk being a bit lower, i may have been calmer about the situation and perhaps gone for regular screening as opposed to such drastic surgery. I always thought that it would kill me so i wanted them off. It is a big operation and it is. Something that is life changing. The womens chances of developing breast comes could have been much lower but it was not possible to tell. Charlie has the same mutation is Angelina Jolie who had her breast tissue and ovaries removed after being told she had up to 87 risk of Breast Cancer. Within six months, women with a Family History of Breast Cancer, could be given a much more accurate assessment in manchester. Thanks to assessment in manchester. Thanks to a new test looking at results and other indicators. It could cut the number bya other indicators. It could cut the number by a third. If you can get the risk below 50 50, women are much more likely to take other preventative measures rather than going for a vasectomy. Scientists had to go further and believe they will be able to give a breakdown of any womens lifetime chance of developing restaurants are using up to 300 genetic variants. The new test could be a game changer. It gives women Early Warning that they carry a genetic risk. Perhaps, even if it has never been in their family before. Scientists are ross investigated whether the research can be used to understand the way genes affect our chances of developing prostate, ovarian, lung and colon rectal councillor. Cancer. The duke of cambridge and prince harry have been open about their own struggles with Mental Health, and set up their charity Heads Together to encourage people to speak out. Now theyve announced the next phase of their mission a £2 Million Investment fund to help improve the nations Mental Health through technology. Our royal correspondent, sarah campbell, has been finding out more. In the run up to the london marathon, the younger royals focus was almost exclusively centred on Heads Together, the campaign they founded, and which aims to improve the Mental Health of the nation. In april, thousands took up the challenge to run the 28 miles and in doing so helped to raise awareness of issues facing millions of people. This has been an unapologetically personal mission, with the princes opening up more than they ever have previously. We hope to make an impact at a younger age. I think we are making good progress. So, has it worked . In a high tech suite in Imperial College london, Prince William was shown data showing their campaign has encouraged more people, especially men, to talk about Mental Health issues. And evidence from the Partner Charities which make up Heads Together suggest a significant impact. The Mental Health charity, mind, had its busiest ever day after the marathon with 58 more calls. The same happened with places2be, which focusses on the Mental Health of children, saw a 148 in downloads to schools. And a 15 increase in calls to young minds parents helpline. Phase one of the campaign was about starting the conversation on Mental Health. Now it is moving on to phase two, Practical Solutions to keep the conversation going. Starting with a £2 million grant from the Royal Foundation to make digital ways to open up. We know we have people struggling late at night with Mental Health, but it is difficult for some services to stay open. The Digital World could help in that space so there is always someone to talk to. As well as digital projects, Heads Together will focus on Mental Health in schools, workplaces, and the military, with this issue remaining at the top of the agenda of the royals. Sarah campbell, bbc news. Teams from around the world are competing in an 18 hundred mile solar powered car race across australia. The world solar challenge aims to Showcase Technology that could one day be used in commercially available cars. The race starts in the Northern City of darwin, crosses the countrys desert heartland, and ends in the adelaide. Paul hawkins has more. Last minute checks for the 3,000 kilometre race from the top of australia to the bottom. 41 teams, mostly from universities and big business, but also some high schools, are competing to see who has the best solar powered vehicle. The field is so far apart. All the cars look different. All we know is we have a good car, we got it running perfect lane were confident well do everything it takes to win. Held every two years, its event organisers want to inspire the brightest young people on the planet to help develop sustainable transport. Overtaking takes up a lot of energy we would not otherwise want to use. We would be happy to be in third where we dont have to evertake that we would be happy to be in third where we dont have to overtake that many cars leaving darwin. It is a gruelling journey from darwin in the north to adelaide in the south coast, travelling across the dry, hot, unwelcoming outback. The vehicles must entirely use the energy of the sun or energy from their own movements. Travellingdy day only, the race is expected to take a week, with most cars reaching speeds of 90 kilometre. The fastest speed was by a Japanese University in 2009 when they completed the in 29 hours and 49 minutes. The fastest cars are expected to reach adelaide on thursday. Now its time for the weather. I think they will run into some showers in the red hot heart of australia. Closer to home, at least portion of sunday, it was a different kettle of fish further north with more cloud. Weather front working their way into scotland. On the mild side across the greater part. Sunshine to encourage it out of the door first thing but no great shocks. Light and patchy rain for the most part. For Northern Ireland, drier with lots of cloud around. Some brightness. Across england and wales, dry and a fine for the most pa rt wales, dry and a fine for the most part but in the south western quarter it is already foggy and it will be the way to start the day and drizzle in the way. None too encouraging. Further east, we beat of brightness first up. We push the weather front away from scotland allowing things to brighton up here. Northern ireland will get sunshine for a time. Brightness across Northern England and wales. And places across the southern parts of england. Temperatures as they have been for a wee wild. More cloud in Northern Ireland. Dry conditions for wales versus the republic of ireland for a world cup qualifying position. After a wet night, on tuesday, the band of whether sinking further south. Only as a band of cloud and the odd passing shower on the breeze. Sunshine coming out for many parts. Boosting temperatures to the upper teens at s. The day finishes ona upper teens at s. The day finishes on a wet and windy note across the North Western quarter of the british isles. Wet and windy wednesday the northern and western parts of the british isles. Further south, a drier prospect and eventually some are brighter and dry weather getting into northern and western parts of scotla nd into northern and western parts of scotland and for Northern Ireland as well. After a quiet start on monday, things turning wet in the middle pa rt things turning wet in the middle part of the week at the second part of the week offers the prospect of a little bit of warmth getting into southern parts of britain. More details on the website. See you again in about half an hour. The papers in a moment. First the headlines at 11 30pm in barcelona, hundreds of thousands demonstrate forunity in spain following catalonias banned independence referendum. Theresa may says shes determined to carry on as Prime Minister as one of her predecessors calls for an end to tory infighting. As the snp conference gets under way, Nicola Sturgeon says she wont think about a timescale on a second independence referendum until the brexit deal becomes clearer. 35 years after the original blade runner 2049 starring