And scotland being taken down a path we did not want, the case becomes ever stronger. Also this hour, the Royal Foundation announces a £2 million grant to help find Digital Solutions to Mental Health problems. Its the largest investment ever made by the Charitable Trust of the duke and duchess of cambridge and prince harry. And in sport at 7. 30, disappointment for scotland as their hopes for qualifying for next yea rs world cup come to an end. And in f1, Lewis Hamilton says he is taking nothing for granted in the title race despite opening a huge lead with victory in the japanese grand prix. Good evening and welcome to bbc news. The former Prime Minister sirjohn major has weighed into the debate over theresa mays future, calling those conservatives who are seeking to undermine her self absorbed and disloyal. Mrs may has admitted her speech at the Party Conference last week had been uncomfortable for her but says shes resilient and determined to carry on in the job. Heres our Political Correspondent chris mason. Lord heseltine called on her to reassert her authority by reshuffling the cabinet. Sirjohn major knows what it is like to be a Prime Minister in peril. It is time to put up or shut up. He saw off his internal critics two decades ago and now he wants to help theresa may do the same. Writing in a sunday newspaper he said that the country has had enough of the self absorbed and frankly disloyal behaviour and, he added, all tory mps must focus their minds instead on the needs of the british people, rather than their own personal ambitions. And, from a former Prime Minister to a future one, at least in the dreams of some tory activists. Both with the same message. We have seen some quite unfortunate shenanigans in terms of a couple of people trying to push, but the pushback has been strong, the Prime Minister is the best person to lead us forward. Borisjohnson, seen by some to be perpetually in the running for the top job and the chief irritant of theresa may said today that those agitating to topple her were nutters, but could, should the Prime Minister sack or move him . The only way that you can avoid leaving him as foreign secretary, with all the difficulties that has created, is to give him a job which is essentially domestic, but you give anyjob to boris and he will still be boris. Downing street sources say talk of a ministerial reshuffle is speculation, but some say it is time for theresa may to freshen up her team. In terms of the reshuffle, because she is staying, because we will remain in thatjob, she has to come out fighting next week and one of the things she will have to do is assert their authority and one of the ways to do that is to have a reshuffle and to bring in some of the brilliant talent. For mrs may today, a quiet day at church with her husband but. Tomorrow mps returned to parliament, brexit negotiations resume in brussels. The Prime Minister will give an update on how the talks are going. It follows a few days in which a series of tory heavy hitters have rallied behind her the home secretary, the foreign secretary and now one of her predecessors, reassuring for her, yes, vindication as well of how precarious position is perceived to be. Chris mason, bbc news, at westminster. A pro unity rally has brought hundreds of thousands of people onto the streets of barcelona, to protest against plans for the region to declare independence from spain. The crowds were addressed by spanish celebrities and politicians who they say represent the silent majority that rejects separatism. The protest comes a week after the Catalan Government went ahead with a referendum on independence, and with the Catalan Parliament due to discuss the situation on tuesday. 0ur correspondent tom burridge reports from barcelona. When the unity of spain is at stake, this happens. People vehemently against catalonia breaking away. Today in barcelona, there were probably more spanish flags than when this country won the football world cup. We want to say we all love catalonia and we are one country. We love spain and it is just one. We understand we have a problem, the relationship between spain and catalonia, but this is not the way to solve it. But the problem, like the crowd today is vast. Some travelled from other regions but most we met live here. The deep uncertainty here has stirred those who say that catalonia is and will remain part of spain and they are angry. They feel they have been ignored by the devolved government in catalonia. People like this person called for the leader of catalonia to be arrested. Born in malaga, barcelona has been her home for 50 years. Translation im here to defend this country for my children and grandchildren. Big business has come out on their side. Two banks which fuelled the powerful economy say they are moving their head offices elsewhere. Richard cotterill has lived and had a business lived and done business in barcelona for several years. I am married to a catalan and my daughters were born here and i have a close link to the city. The spaniards love the catalans, it is not about this feeling that there is a small group of catalans who feel that this is a state where no one loves them, it is nonsense. For her and the Spanish Government, the constitution is under attack. In a newspaper interview, the spanish Prime Minister said he would if necessary take control of the catalonia government. Translation they should know that my government will make sure that any declaration of independence has no meaning. Spain will continue to be spain and it will remain that way for a long time. His conservative Popular Party is not popular in this region. But today was a vote of confidence for madrids uncompromising opposition to independence and last weeks disputed referendum. Paul preston is a professor of contemporary spanish studies at the London School of economics. Hejoins me now. Thank you. How unified is spain . We see thousands out on the street but what does that tell us . Spain has been deeply divided since the civil warand in many been deeply divided since the civil war and in many respects still is. 0ver war and in many respects still is. Over this issue, catalonia is divided broadly between a small majority who want autonomy and not independence and those who want independence. The rest of spain is divided between those who would like dialogue and a small minority of militants who hate catalonia and would love to see tanks rolling. We have breaking news. Our europe editor has spoken to a member of the cata la n editor has spoken to a member of the Catalan Parliament. She says on tuesday there will be a symbolic statement that will stop short of making a unilateral independence declaration. That does not surprise me and notjust because you told me before. He has been pulling back as more evidence has been coming out about what an Economic Disaster a unilateral deck relation of independence would be. At the same time, declaration of independence would be. The Spanish Government has made tentative moves to an apology and it looks like the possibility of dialogue. For that to work it would meana dialogue. For that to work it would mean a move back to the extensive autonomy statute pulled down by the present conservative party when in opposition in 2010. That has to be the goalfor opposition in 2010. That has to be the goal for both sides. How isolated politically would a self declared independent catalonia be . Ithink self declared independent catalonia be . I think totally. 0bviously self declared independent catalonia be . I think totally. Obviously it would be isolated from the rest of spain and from the european union. Within catalonia, it is difficult to say. The opinion poll figures from before last saturdays violence, things would have changed because of the violence but it would be reasonable to say there is half of cata la ns reasonable to say there is half of catalans that would be opposed to a government that did declare unilateral independence. The kings rare intervention raised eyebrows. How does he go back from that . I was asked what i thought he would say andi asked what i thought he would say and i said here is a man whose role is to be a neutral head of state. He will call for dialogue and call for calm. So i was astonished when he came out in the way he did. I think he has seriously undermined his position as the neutral head of state. If for instance he had said a bit of his speech in catalan and said he regretted the violence. These are things that could have mollified what happened. Constitutional monarchs say what the governing party tells them to say. They read out the speech written for them. If the Popular Party gets softer, maybe he can do so as well. If there are voices in catalonia who wa nt to if there are voices in catalonia who want to be on this path to independence, how likely is it the Spanish Government will at this point offer them more devolved power . At this minute, literally, 8pm on sunday, i doubt it. Everything that Mariano Rajoy has done so far suggests a certain boneheaded headedness. An awareness of electoral benefit to be arrived for being anti catalan. At this minute i would not think it likely but there will be other parties, not least the european union, suggesting this needs agreement and dialogue. |j have this needs agreement and dialogue. have a feeling we will see more of you. That will be nice thank you. The snp leader Nicola Sturgeon says she wont think about the timescale for another Scottish Independence referendum until the brexit deal becomes clear. She had previously talked about holding a second vote as early next autumn. And, as the Party Gathers in glasgow for its annual conference, some believe its focus should shift to a second referendum on brexit. 0ur Political Correspondent iain watson reports. Scotlands largest city voted for a very different future in 2014 when a majority of voters here backed independence. It seemed today that the snp leader was backing away from another independence referendum any time soon. There are many people in scotland who want to see scotland become independent, others are not convinced and will never be convinced and others perhaps think we need a bit of dust to settle on brexit. Compare that with what she said in march. If scotland is to have a real choice, when the terms of brexit are known, but before it is too late to choose our own course, then that choice must be offered between the autumn of next year, 2018, and the spring of 2019. What has changed . There is the small matter of a general election where the snp lost a third of their seats at westminster and now this conference, an snp conference, independence is not even formally on the agenda and privately, some of the most senior Party Figures are saying, do not expect to see a second independence referendum before the next Scottish Parliament elections in 2021. Here is perhaps the reason why the snp leadership are reflecting on the timescale for independence. I think she should hold her horses and wait. The quiet man always wins, but why . Just because of everything happening with brexit. Concentrate on brexit. She is going to have a referendum on brexit, one thing at a time. This former adviser to the previous first minister is suggesting there could be more interest on a referendum on brexit in the short term than on independence. By virtue of the fact that brexit is real and is underway, that is bound to be where the focus is and for those, not least the 62 of people in scotland to vote to remain, have an interest in seeing whether brexit can be stopped, democratically. In the meantime, the Scottish Government say they will do what they can to protect the rights of eu citizens here but the snp are finding that opposition to brexit in scotland is not translating into higher levels of support for independence. The man arrested after a car crash outside Londons Natural History Museum yesterday has been released by police, but remains under investigation. The 47 year old was one of 11 people hurt when his toyota prius mounted the pavement and hit pedestrians. Police said the incident was a Traffic Accident and not terrorism related. A woman who tried to scale the front gates of Buckingham Palace has been charged with drunk and disorderly according to scotland yard. She was detained before gaining access to the palace grounds. The police said the palace grounds. The police said the incident is not being treated as terror related. Hurricane nate has hit the united states, bringing torrential rain and powerful winds to communities along the southern coast. Since making landfall, it has now been downgraded to a tropical storm. But weather experts warn the threat of dangerous storm surges remain. After claiming at least 30 lives in central america, it became the fourth major storm to make landfall in the us this year. Anisa kadri reports. As it approached, Hurricane Nate promised strong winds and torrential rain. It hit the gulf coast of the united states, causing flooding in parts of mississippi, alabama, florida and louisiana, where people have been ordered to evacuate. Although it is weakening, the impact is still being felt. We are still seeing wind gusts between 70 and 80 mph. About two miles inland. So weve got about seven to ten feet of storm surge. So our First Responders are kind of overwhelmed right now. The force of nature has already devastated central america, killing at least 25 people. In nicaragua, honduras and costa rica, where hundreds of thousands of people are reported to be without running water. And scenes like these have become all too familiar in the past few months. After back to back hurricanes irma and maria, people in the caribbean have been left without homes, power or clean water. Visiting the islands to see the damage, the un secretary general had a stark message. The damage, the un secretary general it is clear, warmer climate means more hurricanes and more devastating hurricanes, and we need to do everything to stop this. We need to make sure that the Paris Agreement on Climate Change is implemented, and more, as the Paris Agreement is not enough, that enhanced commitments are made by all countries around the world, in order to make sure that we are able to dominate this very dramatic evolution. People in new orleans, who remember the devastation of Hurricane Katrina 12 years ago, did what they could to prepare themselves for the impact of nate. But early indications are that they have been spared the worst. Some americans are seeing nate as a near miss, as it is been downgraded from a hurricane to a tropical storm, but there are still warnings of life threatening storm surge flooding. The headlines on bbc news the former Prime Ministerjohn major calls those trying to undermine theresa may self absorbed and disloyal as the debate over her leadership continues. In spain it is thought the Catalan Leader will stop short of making a unilateral independence declaration on tuesday. Nicola sturgeon says she will not think about a timescale on a second independence referendum until the brexit deal becomes clearer. 0ur royal correspondent Sarah Campbell has found out about the next phase of Prince William and prince harrys charity aimed at improving the nations Mental Health. In the run up to the london marathon, the younger royals focus was almost exclusively centred on Heads Together the campaign they founded, and which aims to improve the nations Mental Health. In april, thousands took up the challenge to run the 26 miles and, in doing so, help to raise awareness of an issue that affects millions of people. This has been an unapologetically personal mission, with the princes opening up in a way they hadnt previously. Do you think weve made enough of an impact, or a stepping stone into the schools area at a younger age . I think we are making good progress. So, has it worked . In a high tech suite in Imperial College london, Prince William was shown survey data which indicates their campaign has encouraged more people, and particularly men, to talk about Mental Health issues. And evidence from the Partner Charities which make up Heads Together suggests a significant impact. The Mental Health charity, mind, had its busiest ever day with 58 more calls the day after the marathon. Place2be, which focusses on childrens Mental Health, on childrens Mental Health, has seen a 148 increase in their downloads to schools. And young minds saw a 15 increase in calls to their parents helpline around the time of the marathon. Phase one of the Heads Together campaign was about starting the conversation on Mental Health. Now it is moving on to phase two, which is about Practical Solutions to keep the conversation going. Starting with a £2 million grant from the Royal Foundation to fund digital ways to help people cope with Mental Health issues. Digital allows us to open up the timescale that people can access stuff, so a lot of People Struggle late at night with their Mental Health, and its very difficult for Traditional Services to stay open. Could a digital intervention start working in that space, so theres always someone you can talk to . As well as digital projects, Heads Together will focus on Mental Health in schools, workplaces, and the military, with this issue remaining at the very top of the agenda of the royals. Thank you all very much. Pleasure. Sarah campbell, bbc news. The number of women having surgery to prevent Breast Cancer could be cut by a third, according to the scientists behind a new gene test being developed in manchester. Our Health Correspondent jenny walronds report its sometimes known as the Angelina Jolie gene. The actress had surgery to remove her breast tissue and ovaries after learning she had a brca gene mutation. One in 400 of us have it. Women who test positive for the brca mutations are told their risk of Breast Cancer is up to 87 , but the risk could, in reality, be much lower. Scientists have developed a test that looks at 18 genetic variants that can affect the likelihood of having Breast Cancer. Using these common variant tests and putting them all together in a package means that we can get far better, far more accurate ideas about the risks women are likely to have in their lifetime. These two were tested. Charlie was a carrier and given up to an 87 risk. Annie was told she had a 50 chance. Asa annie was told she had a 50 chance. As a result, both had a mastectomy. 87 is high and i wanted to get rid of them as soon as i could. Had the risk be no i would maybe have thought twice about it and been calmer about the situation and gone for regular screening as opposed to drastic surgery. I thought they would kill me so i wanted them off. It isa would kill me so i wanted them off. It is a big operation. It is something that is life changing. Their chances of developing Breast Cancer could have been much lower, but it was not possible to tell. This research could make a huge difference to the choices made by women with a Family History of Breast Cancer. Scientists here believe it could cut the number of patients having risk reducing surgery by a third. The more that we learn about the genetic components behind these increased risks of developing Breast Cancer in women who have got a Family History of the disease, the better they can make choices about their health, so that hopefully in the future fewer people will be diagnosed with Breast Cancer. The new test is likely to be available on the nhs in manchester in around six months for women at high risk. They want it to be available eventually for all women, and also hope they can extend their work to understand how our genes affect our chances of developing other cancers. Jenny walrond, bbc news, manchester. We seen the doctor from Cancer Research uk in that report. In the study the scientists built on Previous Research that looked at women with a Family History of Breast Cancer. Notjust looking at a broad population of women across the country, it was only women with a Family History. They looked at small genetic changes to letters of dna, then the population, but looking at then the population, but looking at the small changes linked with the risk of Breast Cancer in people with afamily risk of Breast Cancer in people with a Family History of the disease and they found by homing in on a small number of changes, they could accurately predict the risk these women would go want to develop Breast Cancer. At the moment, in terms of genetics, we only know about the genes behind 25 of cases of women developing Breast Cancer who have a Family History of the disease. People with disabilities caused by the drug thalidomide say theyve made a big breakthrough in their campaign for compensation from the government in germany, where the sedative was manufactured. About a50 babies in the uk were born with disabilities after their mothers were prescribed thalidomide, between 1958 and 1961 lets take a look at some of the other stories making the news. Explosions at a fuel depot in ghana have killed at least seven people and injured more than 30 others. The first blast in the capital, accra, last night sent a giant fireball into the sky, forcing residents to flee. Its understood to have triggered a second explosion and a fire at a nearby petrol station. The sister of the north Korean Leader kim jong un has been promoted. Seen here on the right with her brother, kim yo jong is 28 years old. Shes replaced her aunt in the politburo. Her promotion is further evidence of the kim familys grip on the north korean regime. Close to four tonnes of cocaine has been seized after a ship was intercepted in the atlantic. The spanish authorities acted on intelligence provided by the National Crime agency in the uk to intercept the boat between madeira and the azores. The nca says, if sold, the cocaine would have fetched more than £200 million. Seven men have been arrested. One of the most powerful figures in hollywood the film executive Harvey Weinstein is under increasing pressure over Sexual Harassment allegations. The lawyer who had been defending him has quit, and now President Trump has said that hes not surprised by the claims. 0ur north america correspondent laura bicker is in washington this evening. President trump might be keen to comment because Harvey Weinstein was a supporter of Hillary Clinton and a donor to the democrats. He worked in hollywood circles for many years where this seems to have been an open secret. Harvey weinstein produced blockbusters such as pulp fiction, lord of the rings. He has been married to a british Designer Georgina Chapman and she said she will stand by him amid claims of u nwa nted will stand by him amid claims of unwanted physical and Sexual Harassment dating back decades. A report by the New York Times claims he would invite women to his room for business purposes and to nude and asked for a massage or ask them to watch shower. It also claims he settled allegations with eight women, perhaps actors and assistants. When it comes to Harvey Weinstein, he has apologised, saying he will fix himself. His lawyer said some reports in the newspaper are not true and is preparing a lawsuit. But she has since resigned. When it comes to his future in film, the board of his own company said that future will depend on whether or not his therapy progresses. Theres only one week to go until the old pound coins are taken out of circulation. From midnight next sunday the round pound will lose its legal tender status and no longer be accepted in shops and restaurants. People have been urged to spend them, bank them, or give them to charity before then. More than a0 solar powered vehicles are racing through the centre of australia. The cars will travel 1800 miles ina australia. The cars will travel 1800 miles in a week from darwin to adelaide. 26 countries have teams involved in the challenge. As was the case with saturday, at its best there was nothing really much wrong with sunday as evidenced by our weather watcher in york but in other parts of the British Isles there was a lot of cloud. No rain here off the suffolk coast, but it was close run with showers further offshore overnight. Reinforcing cloud coming in across scotland. Dragging rain through the heart of scotland pushing to the northern isles. Cloudy across the British Isles and not a cold night and not a cold start to the new week. It will be disappointing across the greater part of Scotland First thing. Enough cloud for there to be the odd piece of rain. Northern ireland, quite a bit of cloud. The odd piece of rain moving in but not amounting to much. The greater part of england and wales starting dry. Towards the south west, cloud sitting low, so watch out for hill fog and there will be drizzle here. That might fade, the cloud trying to lift. You get the sense that although there will be dry weather to start the week across much of the British Isles, sunshine will be patchy across the greater part of england, and maybe wales, northern england, parts of scotland faring better. Cloudy in Northern Ireland to finish the day. No great issues with the weather for the match between wales and the republic of ireland on monday. On tuesday, weak weather fronts tumble down across england and wales bringing the prospect of rain. Things brighten up nicely until we bring in the next set of weather fronts