Bailey Drewry, 16, caught a bus from Port Fairy early on March 5.
When he didn't return home that afternoon, his family contacted police.
Sergeant Tom Morris from Warrnambool Police Station said that was the last time his family had contact with him.
Bailey boarded a bus but never made it to school.(Supplied Nine)
The teenager has been missing for nearly a week.(Supplied Nine)
"That's quite concerning and we want to make sure that he's okay," he said.
"We followed up with the school, and he unfortunately didn't attend school that day so he wasn't reported as attending school."
Police are investigating whether Bailey's disappearance is connected to 16-year-old Breeana Knowles who went missing from her Warrnambool address just a day after Bailey.