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AstraZeneca's COVID-19 vaccine was not protective against mild-to-moderate disease from either the so-called South African variant (B.1.351) or the wild type virus, an interim analysis of phase Ib/II data found.
Overall vaccine efficacy against mild-to-moderate COVID-19 in South Africa was 21.9% (95% CI -49.9 to 59.8), and efficacy against B.1.351 was 10.4% (95% CI -76.8 to 54.8), reported Shabir Madhi, PhD, of University of the Witwatersrand in Gauteng, South Africa, and colleagues, in the
Previously, pooled efficacy data on the AstraZeneca vaccine from the U.K., Brazil, and South Africa, prior to B.1.351's emergence, showed overall efficacy of 66.7% (95.8% CI 57.4-74.0), as well as 74.6% efficacy against the so-called U.K. variant, B.1.1.7.