MSCI's broadest index of Asia-Pacific shares outside Japan was 1.11% lower and on course for a 1.4% decline in the week. Japan's Nikkei sank 1.35%. The broad sell-off in U.S. Treasuries continued into Asian hours with the yield on 10-year notes touching a fresh 16-year high as investors come to grips with the Federal Reserve's messaging that interest rates may stay higher for longer.