Jan 14, 2021
WEDNESDAY, Jan. 13, 2021 (HealthDay News) — A candidate vaccine, Ad26.COV2.S, with a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized severe acute respiratory syndrome coronavirus 2 spike protein is safe and immunogenic, according to a study published online Jan. 13 in the
New England Journal of Medicine.
Jerald Sadoff, M.D., from Janssen Vaccines and Prevention in Leiden, Netherlands, and colleagues conducted a phase 1-2a trial involving healthy adults ages 18 to 55 years (cohort 1) and 65 years or older (cohort 3). Participants were randomly assigned to receive Ad26.COV2.S at a low dose or high dose or placebo in a single-dose or two-dose schedule.