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The lorry overturned after crashing into Wooldale Road Bridge in Wootton.
Highways England, tweeting about the smash in the early hours of this morning said: "INCIDENT - #A45 #M1 J15 (#M1 #A508 #StonyStratford) to #Wootton (#CollingtreePark #EastHunsbury) Currently CLOSED due to an HGV hitting Wooldale Road bridge and overturning."
They shortly after shared pictures from the scene of the collision stating that officers were waiting for the bridge inspector to arrive as closures remained in place.
The A45 was reopened shortly after 6am this morning.
Northamptonshire Police and the Northamptonshire Fire and Rescue Service have been contacted for comment.