Unbiased screen uncovers γ-secretase targets far beyond amyloid

Using microglia and an unbiased screening method, investigators have identified almost 60 previously unknown targets for γ-secretase. Investigators from KU Leuven and colleagues published their results in Molecular Cell on Nov. 16, 2023.

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,Molecular Cell ,Microglia ,Neurodegeneration ,Amyloid ,γ Secretase ,Semagacestat ,Ku Leuven ,Uk Dementia Research Institute ,