21c Museum Hotels, a multi-venue contemporary art museum and award-winning hospitality brand, is thrilled to announce the opening of its highly anticipated property in the heart of downtown St. Louis. Like all 21c properties, 21c Museum Hotel St. Louis challenges the conventions of both the hospitality and museum worlds, providing a space where travelers and locals can come together to experience contemporary art exhibitions, community-focused cultural programming, and inspired food and beverage options that spark conversation and create connection.