Is the abundance of our panic. These experiences of stress and so on. This is all due to the fact that we live very well. And we are not prepared deep down for death as a normal part of life about death this is a normal part of life, and secondly, we are not even ready for pain. Because pain, as a consequence, leads to death from here. This is not a readiness for pain, and then readiness for it, and even for some kind of discomfort, leads to the fact that you are born as a nation, but to give birth to children. If it is discomfort, he has already dug deep sometimes and stands deep. They are on top, so here is such a story of readiness for death, an important part of life. And here, tell lets talk about it. What does readiness for death mean . Somehow ready, maybe sasha has any ideas . No, by the way, it is very called. Now mikhail is speaking, i really think the sea is such a rule for the civic, and for life for our civilization, thats for sure. Yes, i remember death very deeply. In fact , you have sort of found out that the roots have already sprouted quite deeply, it must be deep. You can even give an example of another example there last year they rested at the sea, and there was such an assault after. This is when the waves were big, which is cool for everyone to ride, there and there children and adults, its cool there, there were little children there, who was cool in this situation, its definitely important, then, you know for sure, who was cool. I was great, thats all. We talk about ourselves, yes, you dont need to talk about everyone. Okay, take me to the company. Well, im a boy there, well, im not a little one , i know how to swim, chalk is always there and went to swim in these waves. There, not far from the coast , he knows that you cant drag me there, i didnt drown, there, besides me, there are many more, of course, an assumption. Okay, and she is standing there on the shore, next to some water near. You are worried. They call me to the shore, where sasha is practically safe there. Yes, i say, lets go to me here, waistdeep water through , lets move away, where there are no waves up to the chest. You are healthy yes. He doesnt say, its not scary, right . You dont say, its not scary, you deny her fear. Yeah, fear is not an external state. Its internal. Say no, its not scary. You are not sick. Youre all right, uh, lets go skiing. Yes . No no, temperature lets go. You may underestimate. You are actually doing this. Its just better to enter the reality in which you live, while you deny that feature. And anya herself denies it. Im straight, well, most likely im sure of it. Here, but you cant do anything about it, that is, in other words, in that situation. She couldnt help but be scared, uh huh and the psychologists who say if you have some kind of phobia you have to go and face your fears and do just that yes. Well, these psychologists. Im honestly ready. Lets leave him like that to criticize, therefore, if a person can meet his fears, dear colleagues, he will do it and without you. But if he came to you, this is already a fact that he cannot do this. Challenge the last days with the box office. Of course, you can then watch it on the computer monitor in your phone. Or on tv but its not the time to see the call, the way it should be seen on a huge screen with amazing sound. We invite you to the cinema. Theretheretheretherethere tututum dress pay azon bank cards with cashback up to 25 open for free in the ozon bank application. Sportmaster discounts up to 50 on all childrens products before i had a free tinkoff Platinum Credit card, and my life was a solid choice. Why choose, if you have enough money for vacation and repairs , you will have time to get the best credit card before august 31 and get free service forever. I remind you to read don quixote before monday. Alice what day is sunday . Okay, alice, read don quixote by monday, turn on the don quixote act the first happiness from the mind with yandex. Station mini polina swam at the sale to buy a smartphone is no longer there, there are no discounts. Take all the hype sale. Keep up with our benefits and wait for new september discounts. Floor fan scarlett for 699 container set for 399 buyers, real super power buy more super power. Give joy how much and when you want a superpower . They are waiting for the bus and she is waiting for the bus. He is also waiting for the bus. You can wait as you like when you know how long you have to wait . Follow by buses in yandex. Maps maps application to the city of inspiration for 479 set of chairs for 4. 000 899. All night long i didnt sleep a wink. It was yours that impressed you so much. Only now i have five of them. She said five. Yes, five times more fun with winx subscription movies and tv shows, watch the content of five online cinemas in one subscription. Wing for just one ruble winx Video Service from rostelecom get nine percent per annum on the balance in rubles moment all savings are insured in the mobile application. This is a psychic podcast, where i am a journalist Natalia Loseva and Mikhail Khors looking for a way out of the most difficult situations todays request came from a husband who says that his wife is afraid of public transport. And the formula works. Dont be afraid with you. Whether it works or not. We see that it does not seem to work. Yes, when they flew together on an airplane. She grabbed me, right there , she squeezed her hand very tightly, right there , she never felt such hugs there, it seems, how we got through it there, yes, lets say there is that she is holding her hand. Everything is fine there about that incident on the plane, which he told there at the first situation during the first braking. She made friends, she calmed herself in a different way, as she said, like, yes, that everything is normal there, she was more worried, and after the second there. Calls there he has this flash here. Well, we see , yes, that there is a resource, there is a backlog for working with this, another question, it is important not to demand from yourself that it goes like this once and for all. Everything, if you have been collecting this for yourself for years head, give me years to work it out, she used to jump there from a bridge there and a relative there at the age of nine, well, in short, a small child drowning there, who was drowning, saved from the water at a depth. Well, by the way, i would have moved it there in a series of these cases. All the same, there was fear, when you saved. I would go there too. It is too. Well, yes, no, there was nothing left. How to decide. Thats why you do it, firstly, its also important to remember that you solve these problems simply not so effectively. How do you want it, like anyway ride in the car. Anyway, there somehow, if you go on the train, your situation is not so good running. Ive worked with random people where people cant even get down the subway, and you can progress, shes progressing again, because there is criticism of this itself. This is a story, and because instead of treating this situation, as you did, now is the first step. Yes to this healing, you tried to devalue it a little bit, like. Well, now well talk. Well agree on everything now. And everything will be lila as it was, everything will be fine. No, it wont, yes, because, uh, bacteria dont know the virus, right . Its okay, its already there. Yes, it is, it needs to be corrected already, but friends, what i see in this story is very interesting and vitally important. I see that you are a team and that anya has a caring person nearby, perhaps sasha was wrong and did something wrong, but sasha is interested. In any case, you are no longer alone. Yes . You already have such a powerful partner , a friend who will be a support left to find a specialist. But its unknown. By the way, im not i mean, again, to offend someone, but here is this story, when you helped another girl in a traumatic situation. Yes, she is very remarkable. Maybe, on the contrary, with sasha being superfluous, neuroticizing herself, they also dont turn anya in. I am also a good specialist this will tell and maybe really dont be surprised if he advises you, sasha from the page for a while from this problem, so here it is again, yes. Ask how yes , well, thats about it already how to work. Here with this first level there are books there is this, well, just a little bit, just without fanaticism to approach this and lets ourselves work it out for ourselves by different specialists. Hypnosis is not hypnosis cpt. And checkpoint pick up the keys to this door, but to pick up the keys to it. You must first move the cabinet that blocks this door and this cabinet is called. I am normal i have no problems or my wife is normal she has no problems. It just blows here as soon as this closet is moved to this keyhole. It is possible to select different keys. Lets talk about yourself for sure this time and maybe, maybe sash you er accept this hypothesis. That taking a step back and saying something to anya it seems that i am with you when you need me, but please contact me, i am more of this problem of yours until i climb. If you need me, please tell me, yes, so that they do not feel loneliness and constantly here it is, uh, do not feel your tension. And maybe, an, how do you like this position, i dont know, we have to try. Yes here, i very much agree with this phrase that it is necessary to try better. Yes, and see what happens maybe this is your tension will not annihilate. Additionally, dear friends. It is important to draw some conclusions at the end of each psychological consultation. Lets start with anna please tell me what was valuable, interesting and important for you. If it sounded, maybe you will say, i already knew all this. And in general, in fact, the most important thing that i noted for myself now is to try. Even maybe. Speak aloud before each trip that im sorry, im going to scream nervous. Yes cry class, yes, that is it try. Here is the option. Here is a confession to pronounce not in oneself to keep what is so now, perhaps there will be some situations. I will be nervous. We will try not to. And how to Say Something in jest. It is at the beginning to eat. Maybe in jest. And maybe not a joke. Yes, it is important to remember that what happens to you is not bad. Just say it out loud, my outbursts, panics. There are bad of my outbreaks, panic attacks. There are bad. Im not bad because of them, im not bad because of them. I just got sick. I just got sick three times. How do you feel about this . Mm, usually okay. Here is a comfortable state, yes, for a normal person, alexander, you took something important for yourself. I made sure that my wife is special so super. And what i probably need is some way to distance myself. So far i dont understand how to do it. Uh, so that she herself may find ways to solve her problem, and in the case when this is necessary. I will come and help. That is, you are also nearby, you all interact simply, and again, less nervous. We are then when they think that what is happening is a disaster, but because a disaster is such an assessment, you know. Its all the end of the world. Bad, trouble. Horror these estimates are wrong. And we rely on reality when we compare events with each other, this is not as good as i would like, but it can be worse than that uhhuh and when we remind ourselves of this, that it can be worse in general. Yes, its better if we go there. But thats just the way it is now. Here we have a much larger resource, because the nervous system is not tense , we have more resources to do something about the situation that is happening to us now. Thank you. And thank you, dear friends, for coming again, those who want to become darker are asking for help. You are great, friends. It was a podcast of the psyche, in which we traditionally searched for these very keys to cabinets, drawers and chests of drawers, which our souls lie our problems. Sometimes you just need to really move the furniture a little bit to see the secret exit doors. In every in this case, the clinical psychologist , ph. D. In psychology, Mikhail Khors, believes in this and suggests the right direction, what to move and what to look for friends in all issues of the podcast projects. You can watch one tv. Ru on the website of channel one. Hello schrodingers code podcast here and im its lead editorinchief of a Popular Science magazine, who is also schrodingers cat and my cohost is bariums cat. He doesnt sew mine, and we are talking simply about complex things and difficult about simple things, and our todays guest konstantin severin, doctor of biological sciences a professor and a person who is now working on a project with the very unconscious name of 100. 000. The genomes of the russians, it sounds right, frightening. I have read comments about this project. There were the craziest versions, including the fact that the genomes of russian people will be sold like oil. It was the most moderate version, and the most terrible sounded like that they want to take away their genomes from the russians or deprive us of dna in order to calm our most active fellow citizens. Lets recall what a genome is, what it means to be a carrier of a Genetic Information, the material carrier of Genetic Information that we pass on to our children, and receive from our parents is a molecule called dna deoxyribonucleic acid, and on this molecule, as on a material wear or as on a magnetic tape, it is written that you are you and i am this i, and baria, is a bar. And the dna molecules are very long in every cell of our body. We have hundreds of trillions of cells containing about 2 m, but these double helixes of dna, which many probably imagine, are small small cells in each are crammed with 2 m. Here are such tiny molecules, here is the dna that is in our cells, it is the same in our body, because we received half of our dna from mom and half from dad, and so all this Genetic Information that makes you you. And me me about the bar bar. Its called a gene, because this information can be read, there is some procedure called sequencing or in russian, probably dna sequencing, where we really just read a set of such genetic letters. These are chemical molecules for convenience. I will call them ags, and t, and here is this long long text in the case of a person. It contains six billion letters and is almost that 6 billion. It is the genome now a more difficult question. What are the russians in terms of genetics, we exist within the political boundaries of our state and for our project the russians. These are residents, but our country does not matter. This is a russian jew, hungarian tatars, or nanais. Its all the russians moreover possessed. And a russian passport, and a person born in england for example, for us he is also a russian, that is, genes are tied in this case to a passport. Yes, but still, the majority of the inhabitants of our country and their ancestors lived, but in these geographical boundaries, with varying degrees of certainty, we are also interested. In particular , demographic genetic diversity is what we call the inhabitants of our country, that is, to understand how, at the gene level , a conditional kumyk differs from a conditional tatar. Can you can yes . And what is generally known about the genetic differences between the ethnic groups existing in russia is better first determine what is generally known about the genetic differences between people. In general , our genome ultimately determines our individuality. Now, if you look at one egg twins, we can often confuse them, but just by looking at them. And its hard to confuse me with you. Yes , and thats what happens because one egg. Twins have almost the same genome they are clones one egg twins occur when one fertilized egg containing the Genetic Information of mom and dad, sharing gives rise to more than one body, but two bodies. Yes, but it is also obvious that e Genetic Information is important so that it determines unconditionally how we look. That is why one of our gemini is similar. Yes, in a sense it is personal data. Sometimes when i give the whole project there, when we work with schoolchildren, and the children are so clear and beautiful. I sometimes discuss with them. Whose genome do you think was determined, what kind of person is this . Its interesting how this person relates to each of us. And they start to think, and then someone betrays in a choked voice. He must have been a very good and kind person. Here i am sure that this is so and we are all good people. Yes, but, in fact, if im not mistaken, some american. No, but one of the genomes the fact is that the procedure for determining the first human genome, and it was a kind of race and was a government program. This was done jointly by the british and americans and was a private event, and each of these works lasted about 10 years and thousands of scientists were involved. It was billions of dollars, actually and but private traders, as it were, won this race, and a person named a cragvertor was identified who led this project. But still, back to how that genome relates to yours or mine, it turns out that we are all people, of course, but in all variations on some topic, and each of us , on average, differs from the other by one dna letter per 1. 000 letters. Well in the dna sequence this way. This is one tenth of a percent difference. This means that if we have a genome of 6 billion letters, then each of us is different from another for 6 million. Positions or mutations, if you like, and these mutations we have can be similar, or they can be completely different , such typos are scattered throughout this text. Well, lets get back to the 100,000 russian genomes project. Well, clearly this is not a secret conspiracy to steal or create our genes. Uh, superweapon, and what is the purpose of scientific medical economic for what this project is being carried out within the framework of technological cooperation with the state the state has a large federal scientific and technical program. Here is the development of genetic technologies. There is an understanding that genetic technologies. We need to develop programs. This is up to the thirtieth year of the planned creation of a genetic genomic center. Where is made if cleaning the creation of the base the project itself is called 100. 000. Plus i am this, well, anyone out there . Well, in this case. I am this is the idea of ​​voluntariness. It must be present here, because it is voluntary. And here i can hand over my genome to be 100,000. No you cant do it because these 100,000. A probably it should be called 100. 000 plus. We need to understand that this is a corporate program, so, uh, basically , dna sequencing is done for employees of the company , their families, and a very significant amount of work is done with medical partners. These are leading medical research centers. That is, if im not sick with something, well , so genetically exotic, then you dont need my genome. We need all genomes, but we are talking about total gene secretion. The goal of the whole genome project. Well for those volunteers who participate in it and the creation of some kind of database analysis, which will then allow you to do a number of things. You can then talk about what it may be needed for, but such an analysis costs money, in fact, a lot of money in the world. And now the price of such an analysis has dropped below 1,000, that is, what 20 years ago it took 10 years to read one genome and about six billion dollars is now done in 2 days and costs less than 1,000, the price has decreased in millions. This is much cooler than with computers. So what will happen in 20 years . Well, 20 years later, well, here it is. We are now beginning to tell you the truth about meanings, because it is absolutely obvious that in 20 years it will cost quite cheaply. Well , just like cell phones with all these classic examples of the development of these technologies. And this technology is transforming na it will change the world, because the analysis of the genomic sequences of each of us, but allows us to predict our genetic risks in life for the development of certain diseases in the course of life makes it possible to predict, and the carriage or absence of carriage of some pathogenic mutations, which is very important to know, for example, when planning a family or when , and the state of new mutations allows you to diagnose new genetic diseases. Imagine even 20 years ago, well, 30 years ago there were about sixty known to be inherited on the following of their genetic diseases. Well, for example, sickle cell anemia, or hemophilia family. Everyone knows there Tsarevich Alexei a. Now their number is calculated. It has not yet reached 10,000, but already more than 6,000, this is definitely a condition that has been identified. By studying and reading the dna of people who obviously had some kind of illness, that is, people went there for some reason, before the family had any , well , some cases, yes, which geneticists could follow, but could not figure out the cause. Now it is being done. In general, its easier than ever to take relatively speaking, parents of grandparents and children who have. In this family, whether or not there is a manifestation of such and such a disease, and after reading their dna , simply compare to make such a one. Well, a Pretty Simple association. Are there any characteristic changes . These are the very misprints of the mutation in those who have the disease manifest itself and in those who do not show it and thus find it. And well, some conditions that are apparently either diagnostic or associated with a disease or cause a disease. What is much more important, the first is needed for diagnosis, the second is needed for treatment now tens of millions of planogenome sequences, and identified and deposited in databases in the us uk european, a very large project. Now it is in the arab countries in china, and so on and so forth, and in russia, in public databases, at best, it is stored well , in accessible databases, if not we are talking about private people who identified this gene in the company in private, well, for their own we are talking about interest, well, less than ten thousand genomes, in general, there is simply no, not because. What and someone really needs it. We just have this technology was not developed and there was not a Single Player who could raise such a project. Well, after all, they read these 100,000 genomes, what can we learn about a country, health, people, ethnic groups . Whats new is a very large country, multinational, geographically diverse and very poorly understood. Here at this genomic level. Yes, and this plays against us, because it is already clear that, uh , that set of these changes is once again 6 million, changes characteristic of each person, living relative to other people, these changes on the one hand make us individuals. But most of these changes dont. We are not smarter or prettier. They are just such a kind of natural variability of a person as a species, but the presence of such a background, if you like, can be very strong. To influence how truly pathogenic and truly harmful mutations, such as those that determine congenital genetic diseases, are manifested. Or, for example, cancer , most cancers manifest themselves in laid not at the level. And when they start you, but just during your life, but little by little, you accumulate additional changes in your dna, and the longer you live, the more they impose. We are a teacher, garyabel said that all of us all of us will die of cancer if we live to see it. So eventually you have some kind of genetic damage that cells lead to the fact that the cells go crazy. Yes, and so, how all these undesirable effects from our point of view occur strongly depend on this genetic background, which is individual to the previous each of us. On the one hand, it is certainly individual, on the other hand. There are, some of it can be enlarged like that. If you want, where some communities are created, but in the most primitive concept, you know, there someone will look at the shape of the nose or Say Something else, and i know who this is why but because most ethnic groups were formed in historical e not very distant times, when some small group of people may be relatives, having separated from a larger group of people, but then gave rise to such a large colony group people tribe people and so on. This means that within the ethnos, and people have a relatively greater number of common mutations of change. With each other than outside this ethnos, this makes them similar in a certain sense, hence it necessarily follows. Thats what, that ethnically specific to the general sets of some changes in dna once again in no way, not affecting the mind, beauty and all the other things that he said are very worried, they can affect the manifestations of some, and how something malicious mutation manifests itself on the one hand, and on the other hand, these same properties. These same general backgrounds can influence which medication a person or people in that group will respond best to. Along the corridor in which corridor along our corridor and where is he going stirlitz silk to muller stirlitz now lets fall asleep sleep for 20 minutes, well, in 20 minutes he will wake up and go to berlin it was a habit developed over the years, like a habit. Watch how stirlitz skillfully gets out of all the troubles, in which the main series of the soviet union gets into this is such a scout for 7 years has not seen his wife, and he just watches sex, no, as they said later. I can hang on any series, because its just very interesting to watch this on sunday on the first and always on one tv. Ru. Varicose veins of the causes of these Health Problems can become bad blood vessels, the drug angionorm helps to improve microcirculation. Reducing the risk of blood clots, removing inflammation and strengthening the walls of the vessels of angionorm, keep the vessels in normed and mafia stingy. Alexander the kids are asking for new backpacks. Discounts come in handy sale hype. Keep up with the profits and wait for new discounts in September School shark pants for 799 animal felttip pens for 299 customers, a real superpower buy more superpower. To give joy as much and when you want the super ability to receive everything at once and even more, for this it is not at all necessary to be a superhero. Farm a free vtb super credit card, go to vtb and everything will turn out what pin code, if a simple question became a quiz, it can help for lunch, it helps to restore memory and attention to the object, so that the head works, get 9 per annum on the balance in rubles with a bank savings account, replenish it and funds at any time, all savings are insured in a mobile application. Meet new activio you are active look at crabiotics from the inside, and to you from the new one, and to the new one im a zombank card with free service its profitable to pay here and there and there we pay pay azone bank cards with cashback up to 25 open for free in the ozon application jar. What is the pin code here . And it looks like you dont remember the correct answer. If a simple question turns into a quiz. It can help, on the contrary, for lunch it helps to improve brain function, restore memory and concentrate. Naot, so that the head works. My name is maxim my name is alina we work for tinkoff support, you never see us, but we will always come to the rescue when you need it. Find a job on the tinkoff. Ru website and become part of a team from the list of the best employers in russia tinkoff he is one. The podcast of schrodingers cat is with you and i am its host grigory tarasevich, together with my colleague the cat couple and our todays guest konstantin severinov, doctor of biological sciences, professor, and we are talking about the project 100,000 russian genomes. Correctly, i understand that when a large amount of the genome is read, it will be possible to go to a regular clinic and the doctor prescribes me pills will take into account. Eh, who am i ethnos mine or personally to him . I believe that this is how it should be. I believe that well, here in this ideal world. Of course, this will just be enough. In general, your genome is already, when you were born, your genome is already with you. So im sure that it will, of course, be determined and will be part of your medical record, and regarding this genome given to you by god, or rather by your parents, then watch how in the course of life that you still have some new mutations then the entrance of life , which, for example, lead to leukemia or why and to cancer here but ideally it should be like this, and the future is most likely limited not technology, per se, because, well, for 1,000. If you can scan, then, probably, it will soon be possible for 100 and probably there will be enough money to store all this, but it will all be limited, and the quality of the analysis and the education of doctors. This is not a russian problem. This is a problem of the whole world, that is, in america, where, for example, all this is very highly developed and there, uh, the leaders of the medical industry groan and say that the doctors of this project do not know anything , most of the doctors who are now treating. They were in medical schools in the nineties. And the fact that, because we are talking about , actually happened literally 10 years ago. They dont know anything about it and they need to fix it. Uh, Educational Programs for doctors. It is very difficult to return to the knowledge of my personal or your personal genome , it will be possible to say that there is a tendency to a heart attack, so you better live very much. And strange things, because all this is statistical data. And here we are living in the real world. And if you hit the wall with your forehead, then this is a certain fact with him would argue here is incredible. Yeah , thats, uh, most of the eh data that comes from this kind of analysis. They are not good at calling them horoscopes. This is very wrong to do, but they are still predictions, because they give you a probability if it is stated that with your particular genome, the probability of such and such a disease is increased. Let 100 times. Yes. You are probably being, if you have a chondriac, you can be very upset, but if it turns out that normally the probability of this disease is very low, for example, five cases per million. Then, if in your particular case, statistically, after analyzing a huge number of people , it turns out that your probability of illness is increased by 100 times. This means only 500 million for you specifically. Do i need to go after that to kill myself against the wall or just relax . No question what to do . This is one example, one question and is it necessary, for example , that is, is it necessary to make any fateful decisions after that, and a separate question is whether you want this information to get into your employer, a separate issue. Do you want a pilot, uh, who pilots a passenger plane, a, to have a lower average risk of sudden death arrest. It would seem that there is a sudden cardiac arrest and death, but it would seem that this would not happen to him, but even if in the case of the genotype it is associated with an increased risk, it is all the same, and not hundreds per million, sort of like this particular person. It makes no sense aha to refuse work. But statistically yes there is not well there is a situation when it is clear what to do. Well, in my opinion, the most classic example is from pku, which defines its very classic, but its also very, very unique. That is, there really is a genetic disease, when if you do not know that you have it, you will die in a young state. And if you change your diet, then you will live. Now happily, however long the other. Its just that later you will pass this same gene to your offspring, and just in case, i repeat, what was discussed, there is such a disease as phenylkeria, which, among other things, in russia it is scanned on the basis of a nadene and they say right away, here you have it, while it does not manifest itself in any way, it sits somewhere in the genes, and somewhere already in adolescence it turns into a terrible disease that can be prevented by fairly simple diets not fatal. Quite tasty even. And heres an example of how to study. The house can prevent diseases, development in general, whether you want to know. Here it is, but its important to know, because in this case its a simple disease, because it can be prevented. Dietary, no matter how you are. The problem is that you do not cure a lot of diseases or predispositions that are revealed as a result. Here is a massive analysis, full of genomic data, they are not the majority almost all of them are not like phenylke tenerii in the sense that there is no valuable advice on what not to do. Well, apart from smoking and drinking. Eh, well, and so on it is impossible to give. Well , for some reason, follow more, maybe, yes, but lets still touch on this one. An ethically difficult topic like genome editing here was born. I have a conditional child. You looked at his genome compared with your giant propensity base, he has, i dont know, for some reason not good. I dont know about gastritis, but gastritis, you can live with it with gastritis. Lets schizophrenia is also a word can also live