It happened around 4:45 a.m. in the 8500 block of Rannie Road near Ryson.
It began in the 8600 block of Rayson when the victim got into some kind of altercation with the driver of another vehicle, according to Houston police.
After fighting in the street, the two vehicles met up on Rannie Road, where a Hispanic man with a beard opened fire into the victim's car, hitting her three to four times, police said.
Another woman was inside the car when it happened, but she was not injured.
The shooter took off in a silver pickup. Detectives were working to identify him and take him into custody. Officers believe they may have found the pickup involved in the 8500 block of Pitner, but no arrests had been made Saturday morning.