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Gene-based blood test for melanoma spread evaluates treatment progress

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A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.
Led by NYU Grossman School of Medicine and Perlmutter Cancer Center researchers, the investigation looked at adults with undetectable levels of freely circulating tumor DNA (ctDNA) four weeks into drug treatment for metastatic melanoma tumors that cannot be removed surgically (unresectable). The study showed that these patients, all of whom had common genetic changes (BRAFV600 mutations) linked to cancer, were living nearly twice as long without cancer growth as those who continued to have detectable levels. ....

United States , France General , New South Wales , Western Australia , Baden Wuberg , University Of Texas , David Polsky , Jennifer Wiggins , Dirk Schadendorf , Los Angeles , Antoni Ribas , Mahrukh Syeda , Matthew Squires , Eduard Gasal , Caroline Robert , Paul Nathan , James Garrett , Alfredw Kopf , Jan Brase , Keith Flaherty , Michael Davies , Broderickc Corless , Jean Jacques Grob , University Of California , Langone Health , Novartis Institute For Biomedical Research In Cambridge ,

Routine blood tests could be key to stopping the silent killer of liver disease

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New research has shown that results of blood tests routinely performed by GPs everywhere contain a hidden fingerprint that can identify people silently developing potentially fatal liver cirrhosis.
The researchers have developed an algorithm to detect this fingerprint that could be freely installed on any clinical computer, making this a low-cost way for GPs to carry out large scale screening using patient data they already hold.
Liver cirrhosis is the second leading disease causing premature death in working-age people (after heart disease). It develops silently and most patients will have no signs or symptoms until they experience a serious medical emergency and the first admission is fatal in one in three patients. Unlike most major diseases, the mortality rate for liver cirrhosis continues to increase and is now four times higher than forty years ago. ....

United Kingdom , Nick Sheron , Teresa Hydes , Michael Moore , Foundation For Liver Research , University Of Southampton , Professor Of Primary Health Care Research , British Liver , Using Standard , Professor Nick Sheron , Liver Research , Prof Sheron , Chief Executive , British Liver Trust , Primary Health Care Research , Medicine Health , Diet Body Weight , Eating Disorders Obesity , Health Care Systems Services , Health Professionals , Internal Medicine , ஒன்றுபட்டது கிஂக்டம் , நிக் ஷெரோன் , தெரசா ஹைட்ஸ் , மைக்கேல் மூர் , அடித்தளம் க்கு கல்லீரல் ஆராய்ச்சி ,

Study provides new insights into the mechanism of bone marrow tissue

Study provides new insights into the mechanism of bone marrow tissue
Imagine a day when clinicians treating people with blood diseases such as leukemia or multiple myeloma can send in requests for laboratories to custom-produce specific types of blood cells to replace those affected by the disease.
That day became one step closer to reality with a new study led by experts at Cincinnati Children s that provides powerful new insights into how bone marrow tissue works.
The study, published Feb. 10, 2021 in
Nature, was led by senior author Daniel Lucas, PhD, and first authors Jizhou Zhang, MD, and Qingqing Wu, PhD, from the Division of Experimental Hematology and Cancer Biology. Co-authors include a team of scientists from Cincinnati Children s and the University of Cincinnati, plus collaborators in Colorado, Texas and Michigan. ....

United States , University Of Cincinnati , Qingqing Wu , Daniel Lucas , Jizhou Zhang , Emily Henderson , Cincinnati Children Hospital Medical Center , Division Of Experimental Hematology , Cincinnati Children , Experimental Hematology , Study Senior Author , Hospital Medical , Pediatric Cell Atlas , Bone Marrow , Cell Production , Blood Vessels , Multiple Myeloma , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் ஸிந்ஸந்யாடீ , டேனியல் லூகாஸ் , எமிலி ஹென்டர்சன் , ஸிந்ஸந்யாடீ குழந்தைகள் மருத்துவமனை மருத்துவ மையம் , பிரிவு ஆஃப் சோதனை ஹீமாட்டாலஜி , ஸிந்ஸந்யாடீ குழந்தைகள் , சோதனை ஹீமாட்டாலஜி , படிப்பு மூத்தவர் நூலாசிரியர் ,

A new strategy to destroy cancer cells using magnetic nanoparticles and fields

The scientists analyzed how magnetic nanoparticles can be manipulated in in vitro conditions to achieve a selective antitumor effect. The method is based on the combined action of nanoparticles and permanent magnetic fields on human tumor cells. ....

Larisa Litvinova , Kateryna Levada , Educational Center Smart Materials , Educational Center , Smart Materials , Biomedical Applications , Cellular Biotechnology , Immanuel Kant Baltic Federal University , Biomedical Environmental Chemical Engineering , Cell Biology , Chemistry Physics Materials Sciences , Medicine Health , Nanotechnology Micromachines , கல்வி மையம் புத்திசாலி பொருட்கள் , கல்வி மையம் , புத்திசாலி பொருட்கள் , உயிர் மருத்துவ பயன்பாடுகள் , செல்லுலார் உயிரி தொழில்நுட்பவியல் , இம்மானுவேல் காந்த் பால்டிக் கூட்டாட்சியின் பல்கலைக்கழகம் , உயிர் மருத்துவ சுற்றுச்சூழல் இரசாயன பொறியியல் , செல் உயிரியல் , வேதியியல் இயற்பியல் பொருட்கள் அறிவியல் , மருந்து ஆரோக்கியம் ,

Tumor microenvironment helps aggressive lymphomas

Date Time
Tumor microenvironment helps aggressive lymphomas
The environment surrounding the cancerous cells of a lymphoma tumor has a strong influence on the progression of these blood-cell cancers and their responses to therapies, according to a new study by Weill Cornell Medicine investigators.
Measuring this molecular and cellular environment, or “microenvironment,” appears to represent a new type of precision-medicine approach to lymphoma classification and treatment.
CoRus13/Creative Commons
Diffuse large B-cell lymphoma.
The team analyzed the patterns of gene activity in tumor samples taken from the lymph nodes of thousands of lymphoma patients. They found that the cells within these tumors, which include both cancer cells and healthy cells, produce molecules that collectively constitute a distinct microenvironment for the tumors, influencing their biology and growth. ....

United States , Weill Cornell , Jim Schnabel , Leandro Cerchietti , John Leonard , American Association For Cancer Research , Division Of Hematology , Weill Cornell Medicine , Creative Commons , Cancer Discovery , American Association , Edward Meyer Cancer Center , Giorgio Inghirami , Cornell University , Irna Sequencing , Patient Outcomes , Cancer Research , ஒன்றுபட்டது மாநிலங்களில் , வெயில் கார்னெல் , ஜிம் ஶ்ந்யாபெல் , ஜான் லியோனார்ட் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , பிரிவு ஆஃப் ஹீமாட்டாலஜி , வெயில் கார்னெல் மருந்து , படைப்பு காமன்ஸ் , புற்றுநோய் கண்டுபிடிப்பு ,