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Jun 1, 2021 Associations seen with many CSF measures, but not beta-amyloid Aortic stiffening was associated with cerebrospinal fluid (CSF) markers of neurodegeneration and Alzheimer’s disease, a cross-sectional study found. “Among our oldest participants, age 74 years and older, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis,” wrote Angela Jefferson, PhD, of Vanderbilt University in Nashville, Tennessee, and co-authors in “Central arterial stiffening may lead to cumulative cerebral microcirculatory damage and blood flow delivery to tissue, resulting in neuroinflammation and neurodegeneration in more advanced age,” the researchers continued. “Collectively, our results suggest arterial stiffness does not primarily affect brain health through amyloidosis but rather through concomitant pathways of injury, though findings must be interprete

United statesNorth carolinaUnited kingdomWake forest universityVanderbilt universityAngela jeffersonPaul smythTimothy hughesIhab hajjarNational institutes of healthVanderbilt university in nashvilleUnited kingdom dementia research instituteSwedish alzheimer foundationSwedish research councilEmory university in atlantaEuropean union joint program for neurodegenerative disorders