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Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits

Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Jing liXi chenYuhang tangYanteng shiJinhong xuLe cuiChen yu zhangYunxing xueXiaohong jiangHaoquan wangDongjin wangGeorge liuHoshun chongJutang liYujing zhangSchool of life sciences

HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target

Date Time Share HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target HKUMed discovers a novel mediator of liver fibrosis and its underlying mechanism that can be a new therapeutic target. The research was led by Dr Ruby Hoo Lai-chong (second from left), Assistant Professor, Department of Pharmacology and Pharmacy, HKUMed and Co-investigator of State Key Laboratory of Pharmaceutical Biotechnology, HKU. Dr Wu Xiaoping (second from right), post-doctoral fellow, Department of Pharmacology and Pharmacy, HKUMed is the first author. Other research team members include: Ms Zong Jiuyu (left) and Ms Zhang Zixuan (right), postgraduate student, Department of Pharmacology and Pharmacy, HKUMed.

United statesHong kongLi jingjingZong jiuyuZhang zixuanWang cunchuanRuby hoo lai chongShu linglingWu xiaopingHealth bureauKey laboratory of pharmaceutical biotechnologyUniversity of hong kong hkumedResearch grants councilDepartment of medicineTechnology programCollaborative research fund

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang s group and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output. Over 100 years after insulin was discovered, it was believed that pancreatic β cells only secreted a single hormone insulin. Pancreatic β cell-derived insulin regulates glucose homeostasis by binding with the insulin receptors located in the liver, skeletal muscle, adipose tissues and other peripheral organs. The discovery of insulin and its receptor was essential to understand the mechanisms controlling glucose homeostasis and the pathogenesis of type 2 diabetes defined by defective insulin secretion, signal transduction and insulin resistance. However, glucose homeos

Jing liUnited kingdomXiang zhangJunfeng zhangAntonio vidal puigDameng liEunyoung leeShibei wangChen yu zhangXiaohong jiangYuchen liuXin daiMingliang zhangYujing zhangWeiping jiaCentury excellent talents in university

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang s group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver. Previously, Chen-Yu Zhang s group identified extracellular miRNA as a new form of cell-to-cell communication. They are among the first that reported the selective secretion of miRNAs under different physiological or pathological states; also, the uptake and function of secreted miRNAs in recipient cells. In the past decade, intensive studies have revealed the role of extracellular miRNAs in a range of biological processes. Thus, as a newly-emerged secretory factor, more insightful studies are needed to further reveal its relevance t

Jing liUnited kingdomXiang zhangJunfeng zhangAntonio vidal puigDameng liEunyoung leeShibei wangChen yu zhangXiaohong jiangYuchen liuXin daiMingliang zhangYujing zhangWeiping jiaCentury excellent talents in university

Health scares in China put extra scrutiny on efficacy of Chinese-made coronavirus vaccines

Health scares in China put extra scrutiny on efficacy of Chinese-made coronavirus vaccines
theglobeandmail.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from theglobeandmail.com Daily Mail and Mail on Sunday newspapers.

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