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Study shows how functional biomaterials rely on interfacial protein layer to transmit signals to living cells

Study shows how functional biomaterials rely on interfacial protein layer to transmit signals to living cells
An interdisciplinary research team at Lehigh University has unraveled how functional biomaterials rely upon an interfacial protein layer to transmit signals to living cells concerning their adhesion, proliferation and overall development.
According to an article published today in
Scientific Reports, the nanoscale features and properties of an underlying substrate do not impact the biological response of cells directly. However, these properties indirectly influence cell behavior through their control over adsorbed proteins.
In the article, Nanostructure of bioactive glass affects bone cell attachment via protein restructuring upon adsorption, the Lehigh team demonstrates that living cells respond to interfacial layer characteristics that arise as a consequence of micro- and nano-scale structures engineered into a substrate material. ....

Krung Thep Mahanakhon , Tia Kowal , Matthias Falk , Himanshu Jain , Ukrit Thamma , Emily Henderson , Lehigh Institute For Functional Materials , Lehigh University , Lehigh College Of Arts , King Mongkut University Of Technology , Lehigh Interdisciplinary Research Institutes , Scientific Reports , Distinguished Chair , Applied Science , Materials Science , Functional Materials , Professor Jain , Cell Biology , Biological Sciences , Stanford Medicine , King Mongkut , Interdisciplinary Research Institutes , Living Cells , தியா கோவல் , மத்தியாஸ் ஃபாக் , ஹிமான்ஷு ஜெயின் ,

Lehigh U. researchers: 'One step closer to unlocking mysteries of the bio/nano interface'

Credit: Lehigh University | Thamma, Kowal, Falk, Jain
An interdisciplinary research team at Lehigh University has unraveled how functional biomaterials rely upon an interfacial protein layer to transmit signals to living cells concerning their adhesion, proliferation and overall development.
According to an article published today in
Scientific Reports, the nanoscale features and properties of an underlying substrate do not impact the biological response of cells directly. However, these properties indirectly influence cell behavior through their control over adsorbed proteins.
In the article, Nanostructure of bioactive glass affects bone cell attachment via protein restructuring upon adsorption, the Lehigh team demonstrates that living cells respond to interfacial layer characteristics that arise as a consequence of micro- and nano-scale structures engineered into a substrate material. These infinitesimally-tiny structures have an enormous impact upon the natur ....

Krung Thep Mahanakhon , Tia Kowal , Matthias Falk , Himanshu Jain , Ukrit Thamma , Lehigh Institute For Functional Materials , Lehigh University , Lehigh College Of Arts , King Mongkut University Of Technology , Lehigh Interdisciplinary Research Institutes , Scientific Reports , Distinguished Chair , Applied Science , Materials Science , Functional Materials , Professor Jain , Cell Biology , Biological Sciences , Stanford Medicine , King Mongkut , Interdisciplinary Research Institutes , Chemistry Physics Materials Sciences , Medicine Health , Technology Engineering Computer Science , Biomedical Environmental Chemical Engineering , Nanotechnology Micromachines ,