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WhiteLab Genomics, specialist in artificial intelligence (AI) dedicated to gene and cell therapies, is entering into a collaboration with ART-TG, Inserm laboratory expert in the preclinical and pharmaceutical development of ex vivo gene therapies.
The two players are joining forces to improve the processes for the bioproduction of lentiviral gene therapy vectors using artificial intelligence.
As part of this partnership, the teams from the Accelerator for technological research in genomic therapies (ART-TG, Inserm US35) and WhiteLab Genomics will use the WhiteLab Genomics CatalystTM platform to generate a database specific to the bioproduction of lentiviral vectors and which will be used to identify the parameters allowing significant increase in the quality of the vectors as well as their production yields, and to reduce the production costs.
Genethon and WhiteLab Genomics Join Forces to Enhance Gene Therapy Through Artificial Intelligence
The alliance will harness the power of artificial intelligence to accelerate development of innovative gene therapies.
As part of this partnership, Genethon teams will use WhiteLab Genomics Catalyst
TM platform to develop new capsids, or vectors, which are essential components for gene therapy products.
While several gene therapy products have already obtained market authorization for the treatment of rare and common diseases, which demonstrates the efficacy of this approach for conditions considered to be incurable, development of these complex therapies continues to face major scientific and technical hurdles. Many vectors used in gene therapy are derivatives of adeno-associated viruses (AAV). Their use has limitations: natural immunization of 30% to 40% of the population and difficulty targeting a specific tissue. As a result, extremely large quantities of vectors are necessary