ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology
Alex s Lemonade Stand Foundation (ALSF), a nonprofit foundation devoted to finding cures for all children with cancer, announces grant award recipients of their Crazy 8 Initiative. The recipients will receive grants totaling more than $18.5 million, which is the single, largest funding commitment from ALSF to date.
The Initiative kicked off in the Fall of 2018 with a meeting that brought together more than 90 scientists from around the world to help define the research landscape in eight key areas of need in order to tackle major obstacles impeding progress toward cures for childhood cancer. Through a rigorous review process, ALSF received over 100 letters of intent from researchers that resulted in 83 full grant applications which were ultimately narrowed down to four projects that will work to accelerate the pace of new cure discovery.
Alex s Lemonade Stand Foundation Gives $18 5M, Largest Amount Yet
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Alex s Lemonade Stand Foundation awards more than $18 5 million
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A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Now, researchers at the Medical College of Wisconsin (MCW) discovered the molecular basis for how this happened. In the process they uncovered principles that scientists can use to design purpose-built nanoscale transformers for use as biosensors, components of molecular machines, and even therapeutics. The findings were published today in
Science. The primary and senior authors of the manuscript, respectively, are MCW researchers Acacia Dishman, MD-PhD student, and Brian Volkman, PhD, professor of biochemistry.
Molecular switches can be used to detect cancer, construct nanoscale machines, and even build cellular computers. Many currently available molecular switches, however, rely on transcription and translation to switch on, and cellular degradation to turn off, meaning that they work slowly and sometimes irreversibly. Turning them on is like