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Sun Apr 18 2021
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found.
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs.
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A possible explanation for why many cancer drugs that kill tumor cells in mouse models won t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School.
The research was published today in
Nature Communications.
In the study, investigators reported the extensive presence of mouse viruses in patient-derived xenografts (PDX). PDX models are developed by implanting human tumor tissues in immune-deficient mice, and are commonly used to help test and develop cancer drugs. What we found is that when you put a human tumor in a mouse, that tumor is not the same as the tumor that was in the cancer patient, said W. Jim Zheng, PhD, professor at the School of Biomedical Informatics and senior author on the study. The majority of tumors we tested were compromised by mouse viruses.
Nanobodies protect against SARS-CoV-2 variants in animal model
As of today, the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 108 million individuals and claimed the lives of nearly 2.7 million globally. This past year management of the COVID-19 pandemic solely relied on non-pharmaceutical interventions such as school closures, physical distancing, shielding of those at heightened risk, and self-isolation of symptomatic cases.
Currently, prophylactic vaccines - developed at an unprecedented pace are being administered across the globe. However, many viral variants are emerging, threatening the success of the on-going efforts. Despite the adopted mitigation strategies, the COVID-19 pandemic requires multiple countermeasures.
SunStar
+ February 06, 2021 THE Chinese New Year is one of the most celebrated holidays in Asia and around the world. The festivities center on centuries-old customs rich in symbolism to drive off bad luck and bring good fortune for the year ahead. These include food, lanterns, dragons and fireworks. The upcoming celebrations may be different from those of previous years, but there are still many ways to safely ring in the new year and attract good luck.
Here are four traditional ways to welcome the Year of the Ox with good energies:
Cleaning one’s house
It is best to start the new year with a clean space to boost one’s mood and motivation. One can get organized with storage bins and baskets from Ashley Furniture. Damaged appliances can be replaced with upgrades from Asian Home Appliances and door handles, clogged toilets and broken window seals can be repaired with the help of tools from True Value. Making sure the house is neat and tidy before the clock stri