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HKUMed identifies rarely documented pharmacogenetic variants commonly found among Hong Kong Chinese, highlighting the potential for personalised medicine

Share In the first and largest study of its kind among Hong Kong Chinese, a research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has identified 531 rare and predicted deleterious variants in 108 pharmacogenes, among which 96 have never been reported in widely recognised databases. However, these variants were commonly found among Hong Kong Chinese, most of whom (93.6%) having at least one of them. Besides, almost all (99.6%) Hong Kong Chinese residents harboured at least one actionable pharmacogenetic variant, which may impact the effectiveness of drug treatment. This study, which demonstrates the potential of pharmacogenetics in personalised prescription of medicine for reduced risk of adverse reactions and enhanced drug efficacy, has been published in 

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