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Changing the Human Genome: What Next for Germline Genome Editing?

Changing the Human Genome: What Next for Germline Genome Editing?
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FILM: Sandy Starr and Professor Robin Lovell-Badge discuss embryo and stem cell research guidelines

FILM: Sandy Starr and Professor Robin Lovell-Badge discuss embryo and stem cell research guidelines This film documents a conversation between Sandy Starr (deputy director of the Progress Educational Trust, or PET, the charity that publishes BioNews) and Professor Robin Lovell-Badge (chair of trustees at PET) about embryo and stem cell research. Professor Lovell-Badge chaired the task force that developed the latest guidelines of the International Society for Stem Cell Research, and he discusses those guidelines here. If you cannot see the film below, click here to view it. The main themes of the conversation are as follows. 00:00 03:02 09:44 10:41 12:35 18:31 20:47 26 May 2021 - by Sandy Starr 

CRISPR genome editing corrects a Duchenne muscular dystrophy deletion mutation in mice

CRISPR genome editing corrects a Duchenne muscular dystrophy deletion mutation in mice Appeared in BioNews 1093 Two genome editing approaches can correct a variety of mutations associated with Duchenne muscular dystrophy (DMD), researchers have shown. DMD is a genetic disorder caused by mutations in the dystrophingene, leading to a fatal decline in muscle integrity. For the first time, researchers have used two CRISPR-based genome editing techniques to correct multiple dystrophin mutations in mice. It is hoped this could pave the way for new genome editing therapies for DMD. Every cell in the human body has three billion letters of DNA sequence in its genome, and this method makes it possible to correct large deletions in the DMD gene by specifically swapping one of these letters, said Professor Eric Olson, of the University of Texas Southwestern Medical Centre in Dallas, and senior author of the study. That level of specificity and efficiency is remarkable, he added.

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