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Date Time Researchers call for greater awareness of unintended consequences of CRISPR gene editing CRISPR-Cas9 genome editing can lead to unintended mutations at the targeted section of DNA in early human embryos, researchers have revealed. This highlights the need for further research into the effects of CRISPR-Cas9 genome editing, especially when used to edit human DNA in laboratory research. We and others are trying to develop and refine the tools to assess these complex mutations. Kathy Niakan CRISPR-Cas9 genome editing is a widely used research tool which allows scientists to remove and replace sections of DNA in cells, allowing them, for example, to study the function of a given gene or to repair mutations. Last year the researchers who developed CRISPR-Cas9 were awarded the Nobel Prize in Chemistry.

United kingdomKathy niakanGregorio alanis lobatoUniversity of cambridgeCambridge strategic research initiative in reproductionUniversity of oxfordUniversity of cambridge centre for trophoblast researchFrancis crick instituteStem cell laboratoryNobel prizeProfessor kathy niakanHuman embryoReproductive physiologyStem cellProfessor dagan wellsTrophoblast research