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 E-Mail A study led by MedUni Vienna (Institute of Cancer Research and Comprehensive Cancer Center Vienna) sheds light on the mechanisms that lead to extremely aggressive metastasis in a particular type of pancreatic cancer, the basal subtype of ductal adenocarcinoma. The results contribute to a better understanding of the disease. The study has recently been published in the leading journal Gut . The most prevalent form of pancreatic cancer, Pancreatic Ductal AdenoCarcinoma (PDAC) is usually divided into two subtypes, a classical subtype and a basal subtype. The latter is highly aggressive and tends towards early metastasis. One of the distinguishing features between the two subtypes is that the classical subtype exhibits the protein GATA6. This is no longer present in the basal subtype, while the protein DeltaNp63 can be detected in this type.

Paola martinelliMeduni vienna institute of cancer researchIngrid shaker nessmann cancer research associationInstitute of cancer researchCancer centerAustrian science fundFellinger cancer researchCancer center viennaMeduni viennaCancer researchComprehensive cancer center viennaPancreatic ductal adenocarcinomaComprehensive cancer centerVienna general hospitalIngrid shaker nessmann cancer researchMedicine health