Research team identifies a way to improve immune response during viral infections
Melbourne researchers have identified a way to improve the immune response in the face of severe viral infections.
It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune exhaustion . Overcoming immune exhaustion is a major goal for the development of new therapies for cancer or severe viral infections.
A team from the Peter Doherty Institute of Infection and Immunity (Doherty Institute) led by University of Melbourne s Dr Sarah Gabriel, Dr Daniel Utzschneider and Professor Axel Kallies has been able to identify why immune exhaustion occurs and how this may be overcome.
Researchers discover way to improve immune response eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.
A collaborative study led by the Monash Biomedicine Discovery Institute (BDI) with the Peter Doherty Institute of Infection and Immunity (Doherty Institute), a joint venture of the University of Melbourne and Royal Melbourne Hospital, has shown that an anti-parasitic drug already available around the world kills the virus within 48 hours.
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-19 spectrum anti-viral activity in vitro, is an inhibitor of the causative virus.
The use of Ivermectin to combat COVID-19 depends on pre-clinical testing and clinical trials, with funding urgently required to progress the work.
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