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RNA modification may protect against liver disease, explain liver fat differences between sexes

RNA modification may protect against liver disease, explain liver fat differences between sexes
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Researchers make 'bombshell' discovery of an entirely new kind of biomolecule

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Researchers make ‘bombshell’ discovery of an entirely new kind of biomolecule
A newfound biomolecule, consisting of RNA modified by sugars, could be present in all forms of life and might contribute to autoimmune disease.
By Holly Alyssa MacCormick
Stanford researchers have discovered a new kind of biomolecule that could play a significant role in the biology of all living things.
The novel biomolecule, dubbed glycoRNA, is a small ribbon of ribonucleic acid (RNA) with sugar molecules, called glycans, dangling from it. Up until now, the only kinds of similarly sugar-decorated biomolecules known to science were fats (lipids) and proteins. These glycolipids and glycoproteins appear ubiquitously in and on animal, plant and microbial cells, contributing to a wide range of processes essential for life. ....

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Stanford study reveals new biomolecule

A newfound biomolecule, consisting of RNA modified by sugars, could be present in all forms of life and might contribute to autoimmune disease. ....

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New cell atlas of COVID lungs reveals why SARS-CoV-2 is deadly and different

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NEW YORK, NY (April 29, 2021) A new study is drawing the most detailed picture yet of SARS-CoV-2 infection in the lung, revealing mechanisms that result in lethal COVID-19, and may explain long-term complications and show how COVID-19 differs from other infectious diseases.
Led by researchers at Columbia University Vagelos College of Physicians and Surgeons and Herbert Irving Comprehensive Cancer Center, the study found that in patients who died of the infection, COVID-19 unleashed a detrimental trifecta of runaway inflammation, direct destruction and impaired regeneration of lung cells involved in gas exchange, and accelerated lung scarring.
Though the study looked at lungs from patients who had died of the disease, it provides solid leads as to why survivors of severe COVID may experience long-term respiratory complications due to lung scarring. ....

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Six Penn faculty elected to the American Academy of Arts and Sciences

Six Penn faculty elected to the American Academy of Arts and Sciences
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