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 E-Mail The combination of a carb-heavy diet and poor oral hygiene can leave children with early childhood caries (ECC), a severe form of dental decay that can have a lasting impact on their oral and overall health. A few years ago, scientists from Penn s School of Dental Medicine found that the dental plaque that gives rise to ECC is composed of both a bacterial species, Streptococcus mutans, and a fungus, Candida albicans. The two form a sticky symbiosis, known scientifically as a biofilm, that becomes extremely virulent and difficult to displace from the tooth surface. Now, a new study from the group offers a strategy for disrupting this biofilm by targeting the yeast-bacterial interactions that make ECC plaques so intractable. In contrast to some current treatments for ECC, which use antimicrobial agents that can have off-target effects, potentially harming healthy tissues, this treatment uses an enzyme specific to the bonds that exist between microbes.

Geelsu hwangHye eun kimMarwa mohammed barwazirHyun michel kooUniversity of pennsylvania school dental medicineSchool of dental medicinePenn school of dental medicineNational institutes forRestorative sciencesCraniofacial researchDepartment of preventiveDental medicinePenn dental medicinePennsylvania schoolAtul dhallYuan liu