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Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury

Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury
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New York , United States , United Kingdom , Baden Wüberg , Bergisch Gladbach , Nordrhein Westfalen , Masaomi Nangaku , Rieko Matsuda , Miltenyi Biotec , Naoki Kuramoto , Hirokir Ueda , Toshiyuki Ko , Tanabe Ea Susaki , Etsuoa Susaki , Atsuko Nakanishi Ozeki , Shintaro Yamada , Imaris Bitplane , Yu Hirata , Daichi Fukaya , Takashi Taguchi , Issei Komuro , Youichiro Wada , Tsuyoshi Inoue , Wachirasek Peerapanyasut , Sayaka Hayashi , Seitaro Nomura ,

Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution

(
A to
K) Viral load in upper respiratory tract of the 11 patients with COVID-19 at various time points as measured by RT–quantitative PCR (qPCR) (blue symbols). SARS-CoV-2–neutralizing antibody titers in serum/plasma for six severe (A to F; red symbols) and five mild (G to K; green symbols) COVID-19 patients at various time points as determined by PRNT50. (
L to
O) Cytokine levels (L, IL-6; M, IL-8; N, MCP-1; and O, MIP-1β) of fourfold diluted plasma/serum samples at various time points in the 11 patients with COVID-19 as analyzed via a Bio-Plex Pro Human Cytokine Panel 17-Plex assay. ( ....

San Diego , United States , Bio Rad Proteon , Research On Influenza Pathogenesis , National Institute Of Infectious Disease , Institute Of Medical Science , Department Of Health , Drug Administration Research Involving Human Subjects Committee , Japan Agency For Medical Research , B Graham Vaccine Research Center , Graphpad Software Inc , National Institutes Of Health , Human Services , National Institutes Of Allergy , Plex Pro Human Cytokine Panel , University Of Tokyo , University Of Tokyo Institutional Review Board , Japan Program For Infectious Diseases Research , Research Program On , Middle East , Vaccine Research Center , National Institutes , Thermo Fisher Scientific , Sino Biologicals , Fujisawa City Hospital , Research Ethics Review Committees ,