The 13-year-old was last seen on Hepburn Road in Doncaster about 10am.
Police and family have concerns for his welfare as Spencer has autism.
He was last seen wearing red striped flannelette pyjamas and may be headed to Wantirna or Ringwood.
An image has been released of Spencer in the hope someone may recognise him and urge anyone with information to contact Doncaster Police Station on 8841 3999.
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The 23-year-old was last seen going for a walk on in Doncaster East about 2.30pm.
She was wearing a white t-shirt with blue writing on it and denim shorts.
Megan has long brown hair and was carrying a blue bag with a lot of key rings hanging from it.
She may be in the Phillip Island, Kew or Melbourne CBD areas.
Police have concerns for her welfare as she has an intellectual disability.
Police have released an image of Megan in the hope someone recognises her and can provide information on her current whereabouts.
Anyone who sees Megan is urged to contact Doncaster Police Station on 8841 3999.