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Science for just $15 USD. A shared Toll for innate immunity Toll-like receptor 2 (TLR2) is found in various tissues but is best known for its role in the innate immune system of activating sentinel immune cells in response to infection. Using conditional knockout mice, McCoy et al. found that TLR2 also mediated innate immune signaling within the endothelium. TLR2 in endothelial cells activated proinflammatory signaling that promoted angiogenesis and immune cell recruitment in response to various “danger” signals, such as those produced during infection or tissue damage. Endothelial TLR2 also supported tumor growth in a mouse model of prostate cancer. These findings show that the endothelium contributes to innate immune responses and that TLR2 may be a therapeutic target in cancer (see also the Focus by Mahfoud and Petrova).

Antifade mountantMatrigel corningNanodrop thermofisherTrizol thermofisherW heston clevelandS akira osaka universityNational institutes of healthInstitutional biosafety committeeDepartment of neuroscienceLerner research instituteCleveland clinic animal care committeeJackson laboratoryMaterials incTaconic laboratoriesOsaka universityOptimal cutting temperature