Era diventato un rapinatore seriale e pensava di non poter essere scoperto grazie al suo alibi: gli arresti domiciliari a cui era già sottoposto. Ma, al .
Researchers identify new potential mechanism for age-related macular degeneration
Using laboratory-grown roundworms as well as human and mouse eye tissue, University of Maryland School of Medicine (UMSOM) researchers have identified a new potential mechanism for age-related macular degeneration-;the leading cause of blindness among older adults.
The UMSOM researchers say that the findings suggest a new and distinct cause that is different from the previous model of a problematic immune system, showing that the structural organization of the eye s light-detecting cells may be affected by the disease.
The discovery offers the potential to identify new molecular targets to treat the disease. Their discovery was published on April 12 in the
Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells
A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the
Background
SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped RNA virus belonging to the Coronaviridae family. The virus primarily attacks human airway epithelial cells to initiate infection. Mechanistically, the receptor-binding domain (RBD) of the S1 subunit of the viral spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2), which is ubiquitously expressed at the apical surface of host airway epithelial cells. This is
Gene therapy restores vison in dogs with severe form of Leber congenital amaurosis
Gustavo Aguirre and William Beltran, veterinary ophthalmologists and vision scientists at the University of Pennsylvania School of Veterinary Medicine, have studied a wide range of different retinal blinding disorders. But the one caused by mutations in the NPHP5 gene, leading to a form of Leber congenital amaurosis (LCA), is one of the most severe.
Children with this disorder are not visual. They have a wandering, searching look on their faces and are usually diagnosed at a young age.
Gustavo Aguirre, Veterinary Ophthalmologist and Vision Scientist, University of Pennsylvania School of Veterinary Medicine
Editorial Article: Serendipitous rediscovery of neuronal cilia uncovers a previously unknown role
Once considered a vestigial organelle, primary cilia are now believed to have an important function in the central nervous system
10 Mar 2021
Dr. Jannon L. Fuchs and her team at the Fundamental Neuroscience Laboratories (FunNeuroLabs), UNT
While its common knowledge that neurons communicate with each other through an intricate network of axons, dendrites, and synapses, a less-explored aspect of neuronal communication is its sensory response to the surrounding environment. A specialized appendage called primary cilium, found in neurons throughout the brain, is thought to contribute towards rich sensory and signaling systems within neurons. Not too long ago, however, these very cilia were considered to be functionless.