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SNP-Chip: CRISPR-Based Transistor Detects Single Point Mutations SNP-Chip enables amplification-free, electronic, detection of point mutations in DNA from patients with Sickle-Cell Disease and ALS
Long before the COVID-19 pandemic shined a spotlight on CRISPR-based diagnostics, Kiana Aran, PhD, was developing the CRISPR-Chip. It was, according to Aran, the first transistor that uses CRISPR to search the genome for potential mutations. In addition, the graphene field-effect transistor (gFET) did not require amplification or sequencing of the nucleic acid.
Now, two years after its introduction, a group headed by Aran, co-founder and CSO at Cardea Bio, and assistant professor at the Keck Graduate Institute of Applied Life Sciences, is introducing an improved CRISPR-based gFET system, named SNP-Chip.
Photo: Irfan Khan/Los Angeles Times/Polaris
Madison Dabalos, 18, left, and Ixchel Cisneros, 18, wearing face masks walk back to their dorms takeout breakfast from Gastronome at Cal State Fullerton on Aug. 21, 2020.
Photo: Irfan Khan/Los Angeles Times/Polaris
Madison Dabalos, 18, left, and Ixchel Cisneros, 18, wearing face masks walk back to their dorms takeout breakfast from Gastronome at Cal State Fullerton on Aug. 21, 2020.
January 15, 2021
The U.S. Department of Education released $21.2 billion Thursday as part of the coronavirus relief legislation Congress and President Trump approved in December to help colleges and universities nationally. Of that amount, more than $2.83 billion will go to public and private California colleges and universities.