Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury asnjournals.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from asnjournals.org Daily Mail and Mail on Sunday newspapers.
Misregulated gene expression in human hearts can result in cardiovascular diseases that are leading causes of mortality worldwide. However, the limited information on the genomic location of candidate cis-regulatory elements (cCREs) such as enhancers and promoters in distinct cardiac cell types has restricted the understanding of these diseases. Here, we defined >287,000 cCREs in the four chambers of the human heart at single-cell resolution, which revealed cCREs and candidate transcription factors associated with cardiac cell types in a region-dependent manner and during heart failure. We further found cardiovascular disease–associated genetic variants enriched within these cCREs including 38 candidate causal atrial fibrillation variants localized to cardiomyocyte cCREs. Additional functional studies revealed that two of these variants affect a cCRE controlling KCNH2/HERG expression and action potential repolarization. Overall, this atlas of human cardiac cCREs provides the found
Shane Liddelow, PhD
Dr. Liddelow explains how he and his team approached their research, including the initial questions they set out to answer, the roadblocks they encountered, and how they discovered a neurotoxic form of reactive astrocytes. Shane and his team set out to study the interactions between astrocytes and neurons, hoping to better comprehend the functional roles of astrocytes in a range of neurodegenerative diseases.
Watch this webinar to discover:
How astrocyte function changes over time at different stages of disease initiation and progression
How Chromium Single Cell and Visium Spatial Gene Expression can be used to analyze neurodegenerative disease