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Researchers develop novel antibody fragments against SARS coronavirus-2

Researchers develop novel antibody fragments against SARS coronavirus-2 An international research team led by the University of Bonn (Germany) has identified and further developed novel antibody fragments against the SARS coronavirus-2. These nanobodies are much smaller than the classic antibodies used to treat US President Donald Trump, for example. They therefore penetrate the tissue better and can be produced more easily in larger quantities. The researchers at the University Hospital Bonn have also combined the nanobodies into potentially particularly effective molecules. These attack different parts of the virus simultaneously. The approach could prevent the pathogen from evading the active agent through mutations. The results are published in the journal Science.

New promising antibodies against SARS-CoV-2

 E-Mail IMAGE: Cell culture plates with stained cells, in which virus replication can be quantified by the ‚holes that virus infection causes in the cell lawn. view more  Credit: © Volker Lannert/ University of Bonn Antibodies are an important weapon in the immune system s defense against infections. They bind to the surface structures of bacteria or viruses and prevent their replication. One strategy in the fight against disease is therefore to produce effective antibodies in large quantities and inject them into the patients. The outgoing US President Donald Trump probably owes his rapid recovery to this method. However, the antibodies used to treat him have a complex structure, do not penetrate very deeply into the tissue and may cause unwanted complications. Moreover, producing antibodies is difficult and time-consuming. They are therefore probably not suitable for widespread use.

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