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Frontiers | Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus

2School of Biological Sciences, University of Western Australia, Crawley, WA, Australia 3Perron Institute for Neurological and Translational Research, Crawley, WA, Australia Tinnitus, a phantom auditory perception that can seriously affect quality of life, is generally triggered by cochlear trauma and associated with aberrant activity throughout the auditory pathways, often referred to as hyperactivity. Studies suggest that non-auditory structures, such as prefrontal cortex (PFC), may be involved in tinnitus generation, by affecting sensory gating in auditory thalamus, allowing hyperactivity to reach the cortex and lead to perception. Indeed, human studies have shown that repetitive transcranial magnetic stimulation (rTMS) of PFC can alleviate tinnitus. The current study investigated whether this therapeutic effect is achieved through inhibition of thalamic hyperactivity, comparing effects of two common clinical rTMS protocols with sham treatment, in a guinea pig tinnitus model. An

Two existing drugs might be effective for sleep apnoea

While CPAP is an effective treatment for sleep apnoea, many find it too uncomfortable to use; effective drugs would greatly help this group of patients. TNS Sleep apnoea is a condition where the upper airway from the back of the nose to the throat closes repetitively during sleep. This results in a restriction of oxygen intake, causing people to wake as often as 100 times or more per hour. Those with untreated sleep apnoea are more likely to develop cardiovascular disease, dementia and depression. They are also two to four times more likely to crash a car than the general population, due to their fatigue from inadequate sleep.

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