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Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer s Disease

Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer’s Disease In animal models, the new compound modulated a key enzyme, reducing or eliminating production of problematic protein fragments; human clinical trials needed March 02, 2021  |  Scott LaFee News release Amyloid plaques are pathological hallmarks of Alzheimer’s disease (AD) clumps of misfolded proteins that accumulate in the brain, disrupting and killing neurons and resulting in the progressive cognitive impairment that is characteristic of the widespread neurological disorder. In a new study, published March 2, 2021 in the Journal of Experimental Medicine (JEM), researchers at University of California San Diego School of Medicine, Massachusetts General Hospital and elsewhere have identified a new drug that could prevent AD by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques.

New drug prevents hallmark of Alzheimer s disease in animals

New drug prevents hallmark of Alzheimer’s disease in animals Written by Timothy Huzar on March 9, 2021 — Fact checked by Hannah Flynn, MS Alzheimer’s disease affects more than 5 million people in the United States. There is currently no cure. A hallmark of Alzheimer’s is the formation of so-called plaques, which affect the functioning of cells in the brain. In a recent series of studies in animals, scientists have shown that a drug that modulates the behavior of one enzyme reduces the formation of plaques. Scientists have identified a new drug that is effective at inhibiting the development of plaques, a key sign of Alzheimer’s disease, in the brains of animals.

Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer s Disease

Novel Drug Prevents Amyloid Plaques, a Hallmark of Alzheimer s Disease
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