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Epidemics of the Past: Bubonic Plague Bubonic Plague Ashes ? ashes, We all fall down. A familiar nursery rhyme that children have recited as a harmless play song for generations ironically refers to one of Europe s most devastating diseases. The bubonic plague, better known as the ?The Black Death,? has existed for thousands of years. The first recorded case of the plague was in China in 224 B.C.E. But the most significant outbreak was in Europe in the mid-fourteenth century. Over a five-year period from 1347 to 1352, 25 million people died. One-third to one-half of the European population was wiped out! The first symptoms of bubonic plague appeared within days after infection: fever, headache, and a general feeling of weakness, followed by aches in the upper leg and groin, a white tongue, rapid pulse, slurred speech, confusion, and fatigue. By the third day, a painful swelling of the lymph glands in the neck, armpits, and groin occurred, and these enlarged areas were called ?bu

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