Multiple myeloma is a common hematological malignancy that has its origins in plasma cells. Despite treatment becoming more sophisticated, there is still currently no cure. However, immunotherapy targeting CD38/CD3 is proving to be very promising.
CAR-T Therapy: Combating Cytokine Release Syndrome
Sponsored Content by ACROBiosystemsMay 21 2021
CAR-T cell therapy offers the hope of a cure to a number of cancer patients. Yet, in spite of the great effectiveness, more attention has been paid to the toxicity of the therapy known as cytokine release syndrome (CRS).
This article is aimed at summarizing the main points of assessment, grading and management of CRS in CAR-T Therapy and provide answers to the following questions:
How to identify the onset of CRS clinically?
What is CRS management?
How to use tocilizumab in CRS management？
Assessment, grading and management of CRS in CAR-T therapy
Molecule mass
The recombinant Chinese hamster PLBL2 contains a total of 559 amino acids and estimates a molecular mass of 63.3 kDa. Under reducing conditions, the recombinant Chinese hamster PLBD2 migrates as an approximately35.9, 43.8, 65.3 KDa band in SDS-PAGE.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Customers can contact Sino Biological for any concerns or unique needs. Generally, 0.01% Tween80 and 5% to 8% trehalose and mannitol are added as protectants prior to lyophilization. Customers can refer to the specific buffer data provided in the hard copy of CoA.
Shipping
Recombinant proteins are generally delivered as lyophilized powder that is shipped at ambient temperatures. Large recombinant protein packages are delivered as frozen liquid and are shipped with blue ice unless specified by customers.
Controlling a Tumor Microenvironment
Transforming growth factor-beta (TGF-β) is a dynamic cytokine that is part of the transforming growth factor superfamily.
The TGF-β signaling pathway is connected to numerous cellular processes in both the developing embryo and the adult organism, including cell growth, cell differentiation, cellular homeostasis, apoptosis and other cellular functions.
TGF-β signaling in cancer is a complicated process. While TGF-β can facilitate the suppression of tumor formation, conversely, it can also foster it.
In healthy cells and early-stage cancers, TGF-β signaling suppresses tumor formation by impeding cell growth and apoptosis. However, in progressive cancers, TGF-β signaling receives a variety of tumor-promoting effects through specific adaptation or signaling pathways bypass.
CAR-T Therapy: Syndrome Released by Cytokine news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.