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Scientists Identify Brain Cells Most Vulnerable to Alzheimer's Disease

A team of researchers has identified for the first time the neurons that are among the first victims of Alzheimer’s disease. ....

Chan Zuckerberg Biohub , Salvatore Spina , Martin Kampmann , Lea Grinberg , Antonia Piergies , Carlosa Pasqualucci , Alexander Ehrenberg , Kun Leng , Emmi Li , Claudia Kimie Suemoto , Roberta Diehl Rodriguez , Williamw Seeley , Helmut Heinsen , Norma Neff , Renata Elaine Paraizo Leite , Department Of Neurology , Us National Institutes Of Health , Neurodegenerative Disease Brain Bank , University Of Wu , Tau Consortium , John Douglas French Alzheimer Foundation Endowed Professor , Institute For Neurodegenerative Diseases , Alzheimer Association , Weill Institute For Neurosciences , Nature Neuroscience , Neurodegenerative Diseases ,

Brain Cells Most Vulnerable to Alzheimer's Disease Identified by Scientists


A major mystery in Alzheimer’s disease research is why some brain cells succumb to the creeping pathology of the disease years before symptoms first appear, while others seem impervious to the degeneration surrounding them until the disease’s final stages.  
An image of human brain samples used to study why some brain cells are more vulnerable to Alzheimer’s disease than others.
Image by Rana Eser, UCSF Grinberg lab
Now, in a study published Jan. 10, 2021, in
Nature Neuroscience, a team of molecular biologists and neuropathologists from the UCSF Weill Institute for Neurosciences have joined forces to identify for the first time the neurons that are among the first victims of the disease – accumulating toxic “tangles” and dying off earlier than neighboring cells.   ....

Chan Zuckerberg Biohub , Salvatore Spina , Martin Kampmann , Lea Grinberg , Antonia Piergies , Carlosa Pasqualucci , Alexander Ehrenberg , Kun Leng , Emmi Li , Claudia Kimie Suemoto , Roberta Diehl Rodriguez , Williamw Seeley , Helmut Heinsen , Norma Neff , Renata Elaine Paraizo Leite , Department Of Neurology , Us National Institutes Of Health , Neurodegenerative Disease Brain Bank , University Of Wu , Tau Consortium , John Douglas French Alzheimer Foundation Endowed Professor , Institute For Neurodegenerative Diseases , Alzheimer Association , Weill Institute For Neurosciences , Nature Neuroscience , Neurodegenerative Diseases ,