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Among the most promising therapeutic options for individuals with coronavirus disease 2019 (COVID-19) are monoclonal antibodies (mAbs). In this study, Jones et al . identified, characterized, and tested one such mAb, LY-CoV555, in vitro and in vivo. They found that LY-CoV555 bound to the severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) spike protein and prevented its interaction with angiotensin-converting enzyme 2. Prophylactic treatment with LY-CoV555 protected the upper and lower respiratory tracts of nonhuman primates from becoming infected with SARS-CoV-2. Together, these data support the clinical use of LY-CoV555 for treating patients with COVID-19.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may bridge widespread vaccination campaigns and offer a treatment solution in populations less res
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IMAGE: Scientists at SLAC National Accelerator Laboratory and Stanford University discovered that squeezing a promising lead halide material in a diamond anvil cell (left) produces a so-called black perovskite (right). view more
Credit: Greg Stewart/ SLAC National Accelerator Laboratory
Among the materials known as perovskites, one of the most exciting is a material that can convert sunlight to electricity as efficiently as today s commercial silicon solar cells and has the potential for being much cheaper and easier to manufacture.
There s just one problem: Of the four possible atomic configurations, or phases, this material can take, three are efficient but unstable at room temperature and in ordinary environments, and they quickly revert to the fourth phase, which is completely useless for solar applications.
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Elastic motion makes click beetles click, study finds
Illinois researchers Aimy Wissa, Marianne Alleyne and Ophelia Bolmin studied the motion of a click beetle’s jump and present the first analytical framework to uncover the physics behind ultrafast motion by small animals.
Photo by L. Brian Stauffer
CHAMPAIGN, Ill. Click beetles can propel themselves more than 20 body lengths into the air, and they do so without using their legs. While the jump’s motion has been studied in depth, the physical mechanisms that enable the beetles’ signature clicking maneuver have not. A new study examines the forces behind this super-fast energy release and provides guidelines for studying extreme motion, energy storage and energy release in other small animals like trap-jaw ants and mantis shrimps.
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IMAGE: Illinois researchers Aimy Wissa, Marianne Alleyne and Ophelia Bolmin studied the motion of a click beetle s jump and present the first analytical framework to uncover the physics behind ultrafast motion. view more
Credit: Photo by L. Brian Stauffer
CHAMPAIGN, Ill. Click beetles can propel themselves more than 20 body lengths into the air, and they do so without using their legs. While the jump s motion has been studied in depth, the physical mechanisms that enable the beetles signature clicking maneuver have not. A new study examines the forces behind this super-fast energy release and provides guidelines for studying extreme motion, energy storage and energy release in other small animals like trap-jaw ants and mantis shrimps.