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GLP-1 Receptor Agonist Drugs Effective, Pose Complex Concerns

Drugs like Ozempic, Wegovy and Mounjaro have been around for years, but they've recently been making headlines due to a rise in popularity as weight ....

Delong Li , Victorm Montori , Mindym Mickelson , Bijanj Borah , Manqi Zhang , Chong Zhi Wang , Haiqiang Yao , A Mark Fendrick , Guillermoe Umpierrez , Ericc Polley , Eric Polley , Rodolfoj Galindo , David Kim , Joshuaj Neumiller , Juanp Brito , Josephs Ross , Yuqi Wu , Rozalinag Mccoy , Kavya Sindhu Swarna , Yihong Deng , Jenniferh Hwang , Jeph Herrin , Davidm Kent , Williamh Crown , Davidd Kim , Nature Cardiovascular Research ,

Research shows GLP-1 receptor agonist drugs are ef

Studies from multiple UChicago experts show that while GLP-1RA drugs are extremely effective for weight loss and Type 2 diabetes treatment, there s no one- ....

Rodolfoj Galindo , Victorm Montori , Yuqi Wu , Chong Zhi Wang , Haiqiang Yao , Jenniferh Hwang , Delong Li , Yihong Deng , Kavya Sindhu Swarna , Davidm Kent , Bijanj Borah , Eric Polley , Davidd Kim , Joshuaj Neumiller , Mindym Mickelson , Josephs Ross , Williamh Crown , Guillermoe Umpierrez , Rozalinag Mccoy , Manqi Zhang , Juanp Brito , A Mark Fendrick , Jeph Herrin , David Kim , Ericc Polley , Role Of Alternative Weight Maintenance Program ,

Research shows GLP-1 receptor agonist drugs are ef

Studies from multiple UChicago experts show that while GLP-1RA drugs are extremely effective for weight loss and Type 2 diabetes treatment, there s no one- ....

Juanp Brito , Ericc Polley , A Mark Fendrick , Jeph Herrin , David Kim , Joshuaj Neumiller , Manqi Zhang , Williamh Crown , Rozalinag Mccoy , Guillermoe Umpierrez , Josephs Ross , Mindym Mickelson , Bijanj Borah , Davidm Kent , Kavya Sindhu Swarna , Davidd Kim , Eric Polley , Chong Zhi Wang , Haiqiang Yao , Yuqi Wu , Victorm Montori , Rodolfoj Galindo , Yihong Deng , Jenniferh Hwang , Delong Li , Nature Cardiovascular Research ,

Comparative effectiveness of GLP-1 receptor agonists on glycaemic control, body weight, and lipid profile for type 2 diabetes: systematic review and network meta-analysis

Objective To evaluate the comparative efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycaemic control, body weight, and lipid profile in adults with type 2 diabetes.

Design Systematic review and network meta-analysis.

Data sources PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and Embase from database inception to 19 August 2023.

Eligibility criteria for selecting studies Eligible randomised controlled trials enrolled adults with type 2 diabetes who received GLP-1RA treatments and compared effects with placebo or any GLP-1RA drug, with a follow-up duration of at least 12 weeks. Trials with a crossover design, non-inferiority studies comparing GLP-1RA and other drug classes without a placebo group, using withdrawn drugs, and non-English studies were deemed ineligible.

Results 76 eligible trials involving 15 GLP-1RA drugs and 39 246 participants were included in this network meta-analysis; a ....

United States , Chong Zhi Wang , Delong Li , Haiqiang Yao , Manqi Zhang , Yuqi Wu , Drug Administration , Cinema Confidence In Network Meta , National Natural Science Foundation Of China , Stata Corp , European Association For The Study Of Diabetes , University Of Chinese Medicine Talent Research , American Diabetes Association , Research Funds For The Central Universities , Zhi Wang , Cochrane Central Register , Controlled Trials , European Association , Clarivate Analytics , Webplot Digitizer , Network Meta Analysis , National Natural Science Foundation , Fundamental Research Funds , Central Universities , Beijing University , Open Access ,