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Changed Gene Expression After Heart Surgery Extends Cardiomyocyte Regeneration

Single-nucleus RNA-sequencing in a newborn pig model showed increased cell cycle activity and proliferation in cardiomyocytes, which helped remuscularize the left ventricle after experimental heart attack. ....

S Naqi Raza , Ericy Zhang , Wuming Gong , Jakey Chen , Yang Zhou , Gregoryp Walcott , Jianyi Jay Zhang , Yuhua Wei , Meng Zhao , Yuji Nakada , Danielj Garry , Jiacheng Sun , Thanh Nguyen , Wangping Chen , Division Of Cardiovascular Disease , School Of Medicine , Heersink School Of Medicine , National Institutes Of Health , Department Of Biomedical Engineering , University Of Alabama At Birmingham , School Of Engineering , University Of Minnesota , Informatics Institute , Department Of Medicine , Marnixe Heersink School Of Medicine , Biomedical Engineering ,

Changed gene expression after heart surgery extends cardiomyocyte regeneration

Changed gene expression after heart surgery extends cardiomyocyte regeneration
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S Naqi Raza , Ericy Zhang , Wuming Gong , Jakey Chen , Yang Zhou , Gregoryp Walcott , Jianyi Jay Zhang , Yuhua Wei , Meng Zhao , Yuji Nakada , Danielj Garry , Jiacheng Sun , Thanh Nguyen , Wangping Chen , Division Of Cardiovascular Disease , School Of Medicine , Heersink School Of Medicine , National Institutes Of Health , Department Of Biomedical Engineering , University Of Alabama At Birmingham , School Of Engineering , University Of Minnesota , Informatics Institute , Department Of Medicine , Marnixe Heersink School Of Medicine , Biomedical Engineering ,

Slow release of drug, TT-10, improves heart attack recovery in mouse model

BIRMINGHAM, Ala. – A heart attack kills heart muscle cells, leading to a scar that weakens the heart, often leading to eventual heart failure. The ....

Yang Zhou , Danielle Pretorius , Jinfu Yang , Yuji Nakada , Wangping Chen , Jianyi Jay Zhang , School Of Engineering , School Of Medicine , National Institutes Of Health , Department Of Biomedical Engineering , Central South University , Biomedical Engineering , Second Xiangya Hospital , Central South , National Institutes , Gillian Goodrich Endowed Chair ,

Heart attack recovery aided by injecting heart muscle cells that overexpress cyclin D2

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IMAGE: These results suggest that the cyclin D2-cardiomyocyte transplantation may be a potential therapeutic strategy for the repair of infarcted hearts, said study leader Jianyi Jay Zhang, M.D., Ph.D., the chair.
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Credit: UAB
BIRMINGHAM, Ala. - In a large-animal study, researchers have shown that heart attack recovery is aided by injection of heart muscle cells derived from human induced pluripotent stem cell line, or hiPSCs, that overexpress cyclin D2. This research, published in the journal
Circulation, used a pig model of heart attacks, which more closely resembles the human heart in size and physiology, and thus has higher clinical relevance to human disease, compared to studies in mice. ....

United States , Vahid Serpooshan , Yuxin Chu , Gregoryp Walcott , Jianyi Jay Zhang , Yuhua Wei , Antonv Borovjagin , Meng Zhao , Yuji Nakada , Wuqiang Zhu , Thanh Nguyen , Division Of Cardiovascular Disease , School Of Medicine , Emory University , National Institutes Of Health , Department Of Biomedical Engineering , Georgia Institute Of Technology , Department Of Cardiovascular Diseases , University Of Alabama At Birmingham , School Of Engineering , Informatics Institute , Department Of Medicine , Biomedical Engineering , Weihua Bian , Min Xie , Cardiovascular Disease ,

Three longtime antibiotics could offer alternative to addictive opioid pain relievers

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IMAGE: This illustration shows the atomic level resolution of the tetracycline antibiotic bound to the EphB1 receptor.
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Credit: UT Southwestern Medical Center
DALLAS - Feb. 22, 2021 - Three decades-old antibiotics administered together can block a type of pain triggered by nerve damage in an animal model, UT Southwestern researchers report. The finding, published online today in
PNAS, could offer an alternative to opioid-based painkillers, addictive prescription medications that are responsible for an epidemic of abuse in the U.S.
Over 100 million Americans are affected by chronic pain, and a quarter of these experience pain on a daily basis, a burden that costs an estimated $600 billion in lost wages and medical expenses each year. For many of these patients - those with cancer, diabetes, or trauma, for example - their pain is neuropathic, meaning it s caused by damage to pain-sensing nerves. ....

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