dose response obtained after the second dose so response obtained after the second dose. so there is a stepwise increase dose. so there is a stepwise increase. this increase in women response increase. this increase in women response will broaden the protection in response will broaden the protection in immune response will broaden protection, in immune response will broaden protection, hopefully against the new variant. that is the first important new variant. that is the first important consideration. the second important important consideration. the second important consideration. the second important consideration is timing. with any important consideration is timing. with any vaccine during a pandemic, we get with any vaccine during a pandemic, we get the with any vaccine during a pandemic, we get the greatest benefit of the vaccine we get the greatest benefit of the vaccine both for individuals and society, vaccine both for individuals and society,