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Toby Maher, MD, PhD: Improving Lung Function with ENV-101 Treatment of Idiopathic Pulmonary Fibrosis

Hedgehog Pathway Inhibitor Improves IPF

Hedgehog pathway signaling inhibitor ENV-101 blocks signals that can lead to lung fibrosis and scarring and may lead to remodeling of early fibrosis.

Ziritaxestat fails to improve lung function in patients with idiopathic pulmonary fibrosis

WASHINGTON — In patients with idiopathic pulmonary fibrosis, yearly lung function decline rates did not improve with two different dosages of ziritaxestat, according to an American Thoracic Society International Conference presentation.“Unfortunately, ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF receiving standard of care,” Toby M.

Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis

These 2 randomized clinical trials compare the efficacy and safety of 2 doses of the autotaxin inhibitor ziritaxestat vs placebo in patients with idiopathic pul