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Sheffield diabetes consultant appointed as national research leader

Sheffield diabetes consultant appointed as national research leader
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UK Marks 100th Anniversary of First Insulin Clinical Trial

UK Marks 100th Anniversary of First Insulin Clinical Trial
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CCBA-Ethiopia Recognized for Impactful Road-Safety Practices

CCBA-Ethiopia Recognized for Impactful Road-Safety Practices
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CCBA-Ethiopia Recognized For Impactful Road-Safety Practices | The Reporter

CCBA-Ethiopia Recognized For Impactful Road-Safety Practices | The Reporter
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Who really benefits from drug combinations and long titrations for pain?

Findings from Solomon Tesfaye and colleagues’ OPTION-DM trial1 are a useful but intellectually challenging contribution to understanding drug treatment of painful neuropathy. It reiterates a popular expert opinion that gabapentin must be given three times daily and “requires a long titration period of up to 2 months to avoid toxicity”.1 Gabapentin and pregabalin have similar elimination half-lives, via renal excretion. Twice daily administration gave pregabalin a marketing advantage when the patent on gabapentin expired.

Solomon-tesfaye

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