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A novel blood serum assay to diagnose neurode

Clusters of abnormally folded α-synuclein proteins, called seeds, trigger the formation of larger aggregates, leading to neurodegenerative disorders known as synucleinopathies. Researchers from Japan have developed a novel assay that can detect α-synuclein seeds in the blood. This new assay is highly sensitive, simple, quick, and can differentiate between synucleinopathies based on structural differences of the amplified seeds. This research was supported by the National Research Program for Neurological Disorders and Mental Health of the Japan Agency for Medical Research and Development (AMED). ....

Bunkyo Ku , Deborah Mcintyre , Daisuke Taniguchi , Michel Mittelbronn , Haruka Kimura , Taiji Tsunemi , Soichiro Kakuta , Nobutaka Hattori , Akihide Kondo , Ayami Okuzumi , Yoko Imamichi , Nobuyuki Nukina , Shinji Saiki , Shuko Nojiri , Taku Hatano , Takeshi Fukuhara , Manabu Funayama , Gen Matsumoto , Yasuo Uchiyama , Development Grants For Dementia , Welfare Sciences Research , Centre Hospitalier De Luxemburg , Technology Innovation Center , Ministry Of Education , Research On Policy Planning , Nagasaki University School Of Medicine ,