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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Uppsala Lan , Devin Sok , Michael Farzan , Isoplates Perkinelmer , Beckman Biomek , Heidolph Titramax , National Institutes Of Health Clinical Center , Bd Sciences , Life Technology , Sino Biological Inc , Thermo Fisher , K Insights Evaluation Software Cytiva , Electron Microscopy Sciences , Beckman Coulter , Proteina Ge Health Science , Library Kit , Genome Analysis Pipeline , National Institutes , Health Clinical Center , Ambulatory Adults , Respiratory Viral Infection , Forma Cryomed , Sino Biological , Thermo Scientific , Bio Layer Interferometry , Aqua Dead Cell Stain ,

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Uppsala Lan , Devin Sok , Michael Farzan , Isoplates Perkinelmer , Beckman Biomek , Heidolph Titramax , National Institutes Of Health Clinical Center , National Cancer Institute , Sino Biological Inc , Us Center , National Cryoem Facility , K Insights Evaluation Software Cytiva , Electron Microscopy Sciences , Ge Health Science , Human Service , Beckman Coulter , Proteina Ge Health Science , Us Public Health Service , Bd Sciences , Us Department Of Health , National Institutes Of Health , Life Technology , Association Of Fabs , Library Kit , Genome Analysis Pipeline , National Institutes ,

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. Here, we generated four neutralizing nanobodies that target the receptor-binding domain of the SARS-CoV-2 spike protein. We defined two distinct binding epitopes using x-ray crystallography and cryo-electron microscopy. Based on the structures, we engineered multivalent nanobodies with more than 100-fold improved neutralizing activity than monovalent nanobodies. Biparatopic nanobody fusions suppressed the emergence of escape mutants. Several nanobody constructs neutralized through receptor-binding competition, while other monovalent and biparatopic nanobodies triggered aberrant activation of the spike fusion machinery. These premature conformational changes in the spike protein forestalled productive fusion, and rendered the virions non-infectious. ....

United States , Baden Wuberg , Nordrhein Westfalen , Karolinska Institutet , Myone Streptavidin , Stephan Poehlmann , Landesuntersuchungsamt Rheinland Pfalz , Biotechnik Gmb , Connie Cepko , Sean Whelan , Ralf Bartenschlager , Microplates Perkin Elmer , Didier Trono , World Reference Center , Biacore Insight Evaluation Software , Ge Healthcare Life Sciences , X Electron Microscopy Sciences , Software Biotek , Cell Signaling Technology Cat , European Bioinformatics Institute , Argonne National Labs , Ge Healthcare , Zhenjiang Lehua Technology Co Ltd , Scripps Research Institute , Ted Pella Inc , Harvard Medical School ,