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Potential HIV vaccine component leads to strong protection in primates

To block infection from HIV, a successful vaccine will require a combination of ingredients, including at least three antibody targets and a substance that boosts immune responses. ....

M Anthony Moody , Laura Sutherland , Amanda Eaton , Derekw Cain , Emily Henderson , Thomasn Denny , Kartik Manne , Barton Haynes , Benjamin Mildenberg , S Munir Alam , Markg Lewis , Davidc Montefiori , Xiaozhi Lu , Kevin Saunders , Georgem Shaw , Wiltonb Williams , Robertj Edwards , Sampa Santra , Marka Tomai , Yunfei Wang , Georgeanna Morton , Giovannae Hernandez , Christopherb Fox , Kevin Wiehe , Priyamvada Acharya , R Wes Rountree ,

Potential HIV Vaccine Component Proves Effective in Primate Study

To block infection from HIV, a successful vaccine will require a combination of ingredients, including at least three antibody targets and a substance that boos ....

Laura Sutherland , Amanda Eaton , Derekw Cain , Thomasn Denny , Kartik Manne , Barton Haynes , Benjamin Mildenberg , S Munir Alam , Markg Lewis , Davidc Montefiori , Xiaozhi Lu , Kevin Saunders , Georgem Shaw , Wiltonb Williams , Robertj Edwards , Sampa Santra , Marka Tomai , Yunfei Wang , Georgeanna Morton , Giovannae Hernandez , Christopherb Fox , Anthony Moody , Kevin Wiehe , Priyamvada Acharya , R Wes Rountree , Richard Scearce ,

Duke awarded NIAID funding to develop the next generation of pan-coronavirus vaccines

The National Institute of Allergy and Infectious Diseases has awarded $17.5 million over three years to the Duke Human Vaccine Institute to develop a vaccine that protects against multiple types of coronaviruses and viral variants. ....

Barton Haynes , Sampa Santra , Bette Korber , Emily Henderson , University Of North Carolina At Chapel Hill , National Institute Of Allergy , University Of Pennsylvania , Los Alamos National Laboratory , Duke Human Vaccine Institute , National Institute , Infectious Diseases , Middle Eastern Respiratory Syndrome , North Carolina , Chapel Hill , Vaccine Research , Beth Israel Deaconess Medical , Infectious Diseases , Ars Cov 2 ,

Duke lands $17.5M federal grant to develop next-generation coronavirus vaccine

DURHAM - The National Institute of Allergy and Infectious Diseases (NIAID) has awarded $17.5 million over three years to the Duke Human Vaccine Institute to ....

Barton Haynes , Sampa Santra , Bette Korber , University Of North Carolina At Chapel Hill , National Institute Of Allergy , National Institutes Of Health , University Of Pennsylvania , Los Alamos National Laboratory , Duke Human Vaccine Institute , National Institute , Infectious Diseases , Middle Eastern Respiratory Syndrome , North Carolina , Chapel Hill , Vaccine Research , Beth Israel Deaconess Medical , National Institutes ,

Newly identified antibody can be targeted by HIV vaccines

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DURHAM, N.C. - A newly identified group of antibodies that binds to a coating of sugars on the outer shell of HIV is effective in neutralizing the virus and points to a novel vaccine approach that could also potentially be used against SARS-CoV-2 and fungal pathogens, researchers at the Duke Human Vaccine Institute report.
In a study appearing online May 20 in the journal
Cell, the researchers describe an immune cell found in both monkeys and humans that produces a unique type of anti-glycan antibody. This newly described antibody has the ability to attach to the outer layer of HIV at a patch of glycans the chain-like structures of sugars that are on the surfaces of cells, including the outer shells of viruses. ....

Alberto Bartesaghi , Richard Laga , Kartik Manne , Matthews Lee , Sophie Gobeil , S Munir Alam , Josephr Francica , Wilton Williams , Megan Kopp , R Ryan Meyerhoff , Garnett Kelsoe , Marioj Borgnia , Gregoryd Sempowski , Kevin Wiehe , Katayoun Mansouri , Mattia Bonsignori , Guillaume Stewart Jones , Bhavna Hora , Andrew Foulger , Robertj Parks , M Anthony Moody , Celiac Labranche , Allenl Hsu , Barton Haynes , Madison Berry , Margaret Deyton ,